Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease

Antonino Mazzone, Davide Pasotti, Stefano De Servi, Gianluca Fossati, Iolanda Hazzucchelli, Paola Cavigliano, Giovanni Ricevuti

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Abstract

Recent studies suggest that granulocytes (PMNs) play a role in the pathogenesis of acute and chronic myocardial ischemia and extension of myocardial injury. Rabbit-derived antiseram-dependent reduction of circulating PMNs in the dog or using monoclonal antibody anti-CD11b/CD 18 of PMNs resulted in smaller myocardial infarcts. Experience in humans shows the modification of PMN function in angina and during myocardial ischemia. In our studies, patients affected by coronary artery disease presented an increase in granulocyte aggregability in coronary sinus and showed a related higher expression of CD11b/CD18 in coronary sinus with respect to aorta leukocytes. The potential role of this modification of PMNs was analyzed.

Original languageEnglish
Pages (from-to)315-323
Number of pages9
JournalInflammation
Volume16
Issue number4
DOIs
Publication statusPublished - Aug 1992

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ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

Cite this

Mazzone, A., Pasotti, D., De Servi, S., Fossati, G., Hazzucchelli, I., Cavigliano, P., & Ricevuti, G. (1992). Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease. Inflammation, 16(4), 315-323. https://doi.org/10.1007/BF00917624