Correlation between Choline Peak at MR Spectroscopy and Calcium-Sensing Receptor Expression Level in Breast Cancer: A Preliminary Clinical Study

Gabriella Baio, Giuseppe Rescinito, Francesca Rosa, Daniele Pace, Simona Boccardo, Luca Basso, Sandra Salvi, Massimo Calabrese, Mauro Truini, Carlo Emanuele Neumaier

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The calcium-sensing receptor (CaSR) is overexpressed in many pathological states including breast cancer. Since choline kinase may be activated in breast cancer cells by CaSR resulting in increased phosphocholine production, we sought to correlate the total choline peak in breast lesions as measured by in vivo proton magnetic resonance spectroscopy (1H-MRS) with the CaSR expression levels in surgical specimens. Procedures: Thirty-six patients with breast lesions were MR scanned at 3T scanner. Tumour morphology and DCE-MR kinetics were evaluated. 1H-MRS was applied for Cho detection and compared with the CaSR immunohistochemistry analysis (score 0–5) on surgical breast specimens. Results: Thirty-four lesions demonstrated a DCE malignant kinetics curve (types 2 and 3), while two lesions showed a benign (type 1). Twenty of the 23 breast cancer lesions (87 %) with a consistent Cho peak expressed a CaSR score of 3–5, and ten of the 11 breast lesions negative for Cho (91 %) had a CaSR score of 1–2. The two benign lesions showed a non-uniform/weak intense expression of the CaSR (score 3) with a consistent Cho peak. Conclusions: The presence or absence of choline peak evaluated by 1H-MRS, well correlated with the expression of CaSR in patients with breast lesions (p <0.01), supports the hypothesis that CaSR may play an important role in the production of choline in breast cancer.

Original languageEnglish
Pages (from-to)548-556
Number of pages9
JournalMolecular Imaging and Biology
Volume17
Issue number4
DOIs
Publication statusPublished - Jan 23 2015

Keywords

  • 3T MR
  • Breast cancer
  • Calcium channels
  • Calcium-sensing receptor
  • G protein-coupled receptor
  • Magnetic resonance imaging
  • Molecular imaging cancer
  • MR spectroscopy
  • MRI breast
  • Posphocholine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging

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