Correlation between clinical and morphologic findings in unstable angina

S. De Servi, E. Arbustini, F. Marsico, E. Bramucci, L. Angoli, E. Porcu, A. M. Costante, J. Kubica, E. Boschetti, P. Valentini, G. Specchia

Research output: Contribution to journalArticle


This study was undertaken to verify the hypothesis that the discrepant findings in published reports on the prevalence of thrombus in unstable angina depend on the inclusion of different clinical subsets in the various studies. We therefore correlated the clinical characteristics of patients included under the label of unstable angina with the morphologic features assessed by coronary angiography and intravascular ultrasound, and with histopathologic findings of atherectomy specimens. Fifty-eight patients with unstable angina (class B of the Braunwald classification) undergoing coronary arteriography followed by either coronary angioplasty (n = 20) or directional coronary atherectomy (n = 38) were studied. Fifteen patients were in class IB and 43 were in class II to IIIB. Among these 43 patients with angina at rest, 28 had ST-segment elevation during pain, and 15 had ST-segment depression, and 26 developed negative T waves on the baseline electrocardiogram (ECG) as a result of prolonged or repeated episodes of resting chest pain. Intravascular ultrasound examination of the culprit lesion was performed in 43 patients before the interventional procedure, and histopathologic analysis of atherectomy specimens was performed in 38 patients. Complex lesion morphology by angiography was observed in 31 patients (53%) without any significant relation to various clinical subsets. Patients in Braunwald class lB had more calcific plaques than patients in class II to IIIB (p

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalThe American Journal of Cardiology
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    De Servi, S., Arbustini, E., Marsico, F., Bramucci, E., Angoli, L., Porcu, E., Costante, A. M., Kubica, J., Boschetti, E., Valentini, P., & Specchia, G. (1996). Correlation between clinical and morphologic findings in unstable angina. The American Journal of Cardiology, 77(2), 128-132.