Abstract
Objectives: The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas. Methods: 47 consecutive patients were studied, 21 female and 26 male, aged 34.3 (2.8) years. Immunohistochemical analysis was performed on paraffin wax embedded material using monoclonal antibodies directed against the proliferation associated nuclear antigen Ki-67 and cyclin A. Results: The median Ki-67 LI was 8.6% (interquartile range, 4.4%-14.0%). Ki-67 LI was significantly higher in tumours with a heavy inflammatory reaction and diabetes insipidus at presentation, whereas other clinical and histological features were not associated with the proliferation index. There was a strong linear correlation between Ki-67 LI and cyclin A LI (r = 0.77; p
| Original language | English |
|---|---|
| Pages (from-to) | 889-892 |
| Number of pages | 4 |
| Journal | Journal of Neurology, Neurosurgery and Psychiatry |
| Volume | 75 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2004 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
- Neuropsychology and Physiological Psychology
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Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma. / Losa, M.; Vimercati, A.; Acerno, S.; Barzaghi, R. L.; Mortini, P.; Mangili, F.; Terreni, M. R.; Santambrogio, G.; Giovanelli, M.
In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 75, No. 6, 06.2004, p. 889-892.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma
AU - Losa, M.
AU - Vimercati, A.
AU - Acerno, S.
AU - Barzaghi, R. L.
AU - Mortini, P.
AU - Mangili, F.
AU - Terreni, M. R.
AU - Santambrogio, G.
AU - Giovanelli, M.
PY - 2004/6
Y1 - 2004/6
N2 - Objectives: The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas. Methods: 47 consecutive patients were studied, 21 female and 26 male, aged 34.3 (2.8) years. Immunohistochemical analysis was performed on paraffin wax embedded material using monoclonal antibodies directed against the proliferation associated nuclear antigen Ki-67 and cyclin A. Results: The median Ki-67 LI was 8.6% (interquartile range, 4.4%-14.0%). Ki-67 LI was significantly higher in tumours with a heavy inflammatory reaction and diabetes insipidus at presentation, whereas other clinical and histological features were not associated with the proliferation index. There was a strong linear correlation between Ki-67 LI and cyclin A LI (r = 0.77; p
AB - Objectives: The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas. Methods: 47 consecutive patients were studied, 21 female and 26 male, aged 34.3 (2.8) years. Immunohistochemical analysis was performed on paraffin wax embedded material using monoclonal antibodies directed against the proliferation associated nuclear antigen Ki-67 and cyclin A. Results: The median Ki-67 LI was 8.6% (interquartile range, 4.4%-14.0%). Ki-67 LI was significantly higher in tumours with a heavy inflammatory reaction and diabetes insipidus at presentation, whereas other clinical and histological features were not associated with the proliferation index. There was a strong linear correlation between Ki-67 LI and cyclin A LI (r = 0.77; p
UR - http://www.scopus.com/inward/record.url?scp=2442683002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442683002&partnerID=8YFLogxK
U2 - 10.1136/jnnp.2003.012781
DO - 10.1136/jnnp.2003.012781
M3 - Article
C2 - 15146007
AN - SCOPUS:2442683002
VL - 75
SP - 889
EP - 892
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 6
ER -