Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma

M. Losa, A. Vimercati, S. Acerno, R. L. Barzaghi, P. Mortini, F. Mangili, M. R. Terreni, G. Santambrogio, M. Giovanelli

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas. Methods: 47 consecutive patients were studied, 21 female and 26 male, aged 34.3 (2.8) years. Immunohistochemical analysis was performed on paraffin wax embedded material using monoclonal antibodies directed against the proliferation associated nuclear antigen Ki-67 and cyclin A. Results: The median Ki-67 LI was 8.6% (interquartile range, 4.4%-14.0%). Ki-67 LI was significantly higher in tumours with a heavy inflammatory reaction and diabetes insipidus at presentation, whereas other clinical and histological features were not associated with the proliferation index. There was a strong linear correlation between Ki-67 LI and cyclin A LI (r = 0.77; p

Original languageEnglish
Pages (from-to)889-892
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number6
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology


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