Correlation between contractility and proliferation in human fibroblasts

A. Macieira-Coelho, B. Azzarone

Research output: Contribution to journalArticlepeer-review


The contractile power of human fibroblasts was checked through their life span in vitro, using a plasma clot retraction test. It was found to decline with a pattern analogous to that of the different phases identifiable by the study of the kinetics of proliferation of these cells. The capacity to retract a plasma clot was higher in cells harvested during active growth than in cells harvested in resting phase. The decreased ability to retract during aging becomes apparent when cells are harvested in resting phase. Decreased retractile activity was also observed in postnatal cells as compared with embryonic cells. The results support a correlation between the initiation of DNA synthesis and the turnover of cytoskeletal elements. The data fit our previous results showing that the early proliferative disturbance during cellular senescence consists of a decline in the probability of initiating the division cycle linked to impaired cell attachment and spreading.

Original languageEnglish
Pages (from-to)610-614
Number of pages5
JournalJournal of Cellular Physiology
Issue number3
Publication statusPublished - Mar 1990

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology


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