Correlation between disease severity and in vitro cytokine production mediated by MSRV (Multiple Sclerosis associated RetroViral element) envelope protein in patients with multiple sclerosis

Alexandre Rolland, Evelyne Jouvin-Marche, Marina Saresella, Pasquale Ferrante, Rosella Cavaretta, Alain Créange, Patrice Marche, Hervé Perron

Research output: Contribution to journalArticle

Abstract

MSRV is a retroviral element previously isolated in cell cultures from patients with multiple sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a humanized SCID mice model. In the present study, we have evaluated potential links between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus, cytokine productions mediated by the surface unit of MSRV envelope protein were evaluated in PBMC of MS patients and compared with healthy controls. Divergent reactivity to ENV-SU between MS and control PBMC was observed and was reflected by a significant increase of IFN-γ, IL-6 and IL-12p40 production by the tested MS population. Interestingly, the overproduction of IL-6 and IL-12p40 was found to correlate with disease severity (EDSS) in most patients. Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalJournal of Neuroimmunology
Volume160
Issue number1-2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Cytokines
  • Endogenous retrovirus
  • HERV-W
  • Inflammation
  • MSRV
  • Multiple sclerosis
  • Th1/Th2

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Fingerprint Dive into the research topics of 'Correlation between disease severity and in vitro cytokine production mediated by MSRV (Multiple Sclerosis associated RetroViral element) envelope protein in patients with multiple sclerosis'. Together they form a unique fingerprint.

  • Cite this