Abstract
MSRV is a retroviral element previously isolated in cell cultures from patients with multiple sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a humanized SCID mice model. In the present study, we have evaluated potential links between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus, cytokine productions mediated by the surface unit of MSRV envelope protein were evaluated in PBMC of MS patients and compared with healthy controls. Divergent reactivity to ENV-SU between MS and control PBMC was observed and was reflected by a significant increase of IFN-γ, IL-6 and IL-12p40 production by the tested MS population. Interestingly, the overproduction of IL-6 and IL-12p40 was found to correlate with disease severity (EDSS) in most patients. Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS.
| Original language | English |
|---|---|
| Pages (from-to) | 195-203 |
| Number of pages | 9 |
| Journal | Journal of Neuroimmunology |
| Volume | 160 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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Keywords
- Cytokines
- Endogenous retrovirus
- HERV-W
- Inflammation
- MSRV
- Multiple sclerosis
- Th1/Th2
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Correlation between disease severity and in vitro cytokine production mediated by MSRV (Multiple Sclerosis associated RetroViral element) envelope protein in patients with multiple sclerosis. / Rolland, Alexandre; Jouvin-Marche, Evelyne; Saresella, Marina; Ferrante, Pasquale; Cavaretta, Rosella; Créange, Alain; Marche, Patrice; Perron, Hervé.
In: Journal of Neuroimmunology, Vol. 160, No. 1-2, 03.2005, p. 195-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between disease severity and in vitro cytokine production mediated by MSRV (Multiple Sclerosis associated RetroViral element) envelope protein in patients with multiple sclerosis
AU - Rolland, Alexandre
AU - Jouvin-Marche, Evelyne
AU - Saresella, Marina
AU - Ferrante, Pasquale
AU - Cavaretta, Rosella
AU - Créange, Alain
AU - Marche, Patrice
AU - Perron, Hervé
PY - 2005/3
Y1 - 2005/3
N2 - MSRV is a retroviral element previously isolated in cell cultures from patients with multiple sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a humanized SCID mice model. In the present study, we have evaluated potential links between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus, cytokine productions mediated by the surface unit of MSRV envelope protein were evaluated in PBMC of MS patients and compared with healthy controls. Divergent reactivity to ENV-SU between MS and control PBMC was observed and was reflected by a significant increase of IFN-γ, IL-6 and IL-12p40 production by the tested MS population. Interestingly, the overproduction of IL-6 and IL-12p40 was found to correlate with disease severity (EDSS) in most patients. Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS.
AB - MSRV is a retroviral element previously isolated in cell cultures from patients with multiple sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a humanized SCID mice model. In the present study, we have evaluated potential links between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus, cytokine productions mediated by the surface unit of MSRV envelope protein were evaluated in PBMC of MS patients and compared with healthy controls. Divergent reactivity to ENV-SU between MS and control PBMC was observed and was reflected by a significant increase of IFN-γ, IL-6 and IL-12p40 production by the tested MS population. Interestingly, the overproduction of IL-6 and IL-12p40 was found to correlate with disease severity (EDSS) in most patients. Altogether our data suggest that MSRV envelope protein may induce an abnormal cytokine secretion, thus contributing to the inflammatory process in MS.
KW - Cytokines
KW - Endogenous retrovirus
KW - HERV-W
KW - Inflammation
KW - MSRV
KW - Multiple sclerosis
KW - Th1/Th2
UR - http://www.scopus.com/inward/record.url?scp=13844264113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844264113&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2004.10.019
DO - 10.1016/j.jneuroim.2004.10.019
M3 - Article
VL - 160
SP - 195
EP - 203
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -