Correlation between dosage and antipyretic effect of aspirin in children

A. Vigano, A. Dalla Villa, I. Cecchini, G. C. Biasini, N. Principi

Research output: Contribution to journalArticlepeer-review

Abstract

One hundred and forty-five children aged 3 months to 11.5 years, with rectal temperatures greater than 38.9°C, were randomly treated with aspirin 5, 10 or 15 mg/kg p.o. Temperatures were recorded just before medication, every 30 min thereafter for 4 h and subsequently hourly up to 6 h. In all dosage regimens the average temperature was significantly reduced in the time interval 1-6 h after drug administration; the antipyretic effect, however, was significantly greater with the 10 and 15 mg/kg doses. Both had significantly better and comparable clinical efficacy, defined as reduction in fever below 38.9°C. The duration of the clinical effect was not dose-related. A dose of 10 mg/kg appears rational for the treatment of children with fever.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume31
Issue number3
DOIs
Publication statusPublished - May 1986

Keywords

  • aspirin
  • children
  • dose-response
  • fever
  • therapeutic regimen

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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