Correlation between fetal and maternal serum bile acid concentration

Carla Colombo, Aldo Roda, Enrico Roda, Mauro Buscaglia, Carlo Alberto Dell'Agnola, Paola Filippetti, Mariangela Ronchi, Fabio Sereni

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Serum concentrations of different bile acids (BA) were determined by radioimmunoassay in 56 human fetuses and mothers. Serum was obtained immediately after legal abortion, performed between the 14th and the 21st wk of gestation. Conjugated cholic (CCA) and chenodeoxycholic acid (CCDCA) concentrations were determined in 33 cases, conjugated lithocholic (CLCA) and deoxycholic acid (CDCA) in 20, and sulfolithocholyglycine (SLCG) in 15. In fetal blood, mean concentrations of CCA (0.80 ± 0.40 μmol/liter), CCDCA (4.50 ± 2.70 μmol/liter), and CLCA (1.70 ± 1.04 μmol/liter) were significantly higher than those in the mother (CCA 0.34 ± 0.17 μmol/liter; CCDCA 0.79 ± 0.34 μmol/liter; CLCA: 0.70 ± 0.30 μmol/liter; p <0.001); fetal serum levels of CDCA (0.46 ± 0.32 μmol/liter) and SLCG (0.15 ± 0.09 μmol/liter) were lower than in the mothers (CDCA 1.20 ± 0.80 μmol/liter, p <0.001; SLCG 0.40 ± 0.30 μmol/liter, p <0.01). There was no correlation between levels of BA and gestational age. Serum total protein and albumin concentrations were both reduced in 10 fetuses as compared with the mothers. These data support the concept of a state of physiologic cholestasis during development and suggest that placental transfer of primary BA occurs mostly in the fetal to maternal direction. This transfer could be facilitated by the reduced fetal plasma albumin concentration, since BA in free solution diffuse more easily through the placenta. There is evidence of lithocholic acid synthesis in the fetal liver, while deoxycholic acid appears to be mostly of maternal origin. Finally, sulfation of BA is poorly developed at this age of gestation.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalPediatric Research
Volume19
Issue number2
Publication statusPublished - 1985

Fingerprint

Bile Acids and Salts
Deoxycholic Acid
Chenodeoxycholic Acid
Mothers
Lithocholic Acid
Serum
Serum Albumin
Fetus
Legal Abortion
Placentation
Pregnancy
Cholestasis
Fetal Blood
Placenta
Gestational Age
Radioimmunoassay
Blood Proteins
Liver

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Colombo, C., Roda, A., Roda, E., Buscaglia, M., Dell'Agnola, C. A., Filippetti, P., ... Sereni, F. (1985). Correlation between fetal and maternal serum bile acid concentration. Pediatric Research, 19(2), 227-231.

Correlation between fetal and maternal serum bile acid concentration. / Colombo, Carla; Roda, Aldo; Roda, Enrico; Buscaglia, Mauro; Dell'Agnola, Carlo Alberto; Filippetti, Paola; Ronchi, Mariangela; Sereni, Fabio.

In: Pediatric Research, Vol. 19, No. 2, 1985, p. 227-231.

Research output: Contribution to journalArticle

Colombo, C, Roda, A, Roda, E, Buscaglia, M, Dell'Agnola, CA, Filippetti, P, Ronchi, M & Sereni, F 1985, 'Correlation between fetal and maternal serum bile acid concentration', Pediatric Research, vol. 19, no. 2, pp. 227-231.
Colombo C, Roda A, Roda E, Buscaglia M, Dell'Agnola CA, Filippetti P et al. Correlation between fetal and maternal serum bile acid concentration. Pediatric Research. 1985;19(2):227-231.
Colombo, Carla ; Roda, Aldo ; Roda, Enrico ; Buscaglia, Mauro ; Dell'Agnola, Carlo Alberto ; Filippetti, Paola ; Ronchi, Mariangela ; Sereni, Fabio. / Correlation between fetal and maternal serum bile acid concentration. In: Pediatric Research. 1985 ; Vol. 19, No. 2. pp. 227-231.
@article{9fde9f3c6f084d458735e204532f8af6,
title = "Correlation between fetal and maternal serum bile acid concentration",
abstract = "Serum concentrations of different bile acids (BA) were determined by radioimmunoassay in 56 human fetuses and mothers. Serum was obtained immediately after legal abortion, performed between the 14th and the 21st wk of gestation. Conjugated cholic (CCA) and chenodeoxycholic acid (CCDCA) concentrations were determined in 33 cases, conjugated lithocholic (CLCA) and deoxycholic acid (CDCA) in 20, and sulfolithocholyglycine (SLCG) in 15. In fetal blood, mean concentrations of CCA (0.80 ± 0.40 μmol/liter), CCDCA (4.50 ± 2.70 μmol/liter), and CLCA (1.70 ± 1.04 μmol/liter) were significantly higher than those in the mother (CCA 0.34 ± 0.17 μmol/liter; CCDCA 0.79 ± 0.34 μmol/liter; CLCA: 0.70 ± 0.30 μmol/liter; p <0.001); fetal serum levels of CDCA (0.46 ± 0.32 μmol/liter) and SLCG (0.15 ± 0.09 μmol/liter) were lower than in the mothers (CDCA 1.20 ± 0.80 μmol/liter, p <0.001; SLCG 0.40 ± 0.30 μmol/liter, p <0.01). There was no correlation between levels of BA and gestational age. Serum total protein and albumin concentrations were both reduced in 10 fetuses as compared with the mothers. These data support the concept of a state of physiologic cholestasis during development and suggest that placental transfer of primary BA occurs mostly in the fetal to maternal direction. This transfer could be facilitated by the reduced fetal plasma albumin concentration, since BA in free solution diffuse more easily through the placenta. There is evidence of lithocholic acid synthesis in the fetal liver, while deoxycholic acid appears to be mostly of maternal origin. Finally, sulfation of BA is poorly developed at this age of gestation.",
author = "Carla Colombo and Aldo Roda and Enrico Roda and Mauro Buscaglia and Dell'Agnola, {Carlo Alberto} and Paola Filippetti and Mariangela Ronchi and Fabio Sereni",
year = "1985",
language = "English",
volume = "19",
pages = "227--231",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Correlation between fetal and maternal serum bile acid concentration

AU - Colombo, Carla

AU - Roda, Aldo

AU - Roda, Enrico

AU - Buscaglia, Mauro

AU - Dell'Agnola, Carlo Alberto

AU - Filippetti, Paola

AU - Ronchi, Mariangela

AU - Sereni, Fabio

PY - 1985

Y1 - 1985

N2 - Serum concentrations of different bile acids (BA) were determined by radioimmunoassay in 56 human fetuses and mothers. Serum was obtained immediately after legal abortion, performed between the 14th and the 21st wk of gestation. Conjugated cholic (CCA) and chenodeoxycholic acid (CCDCA) concentrations were determined in 33 cases, conjugated lithocholic (CLCA) and deoxycholic acid (CDCA) in 20, and sulfolithocholyglycine (SLCG) in 15. In fetal blood, mean concentrations of CCA (0.80 ± 0.40 μmol/liter), CCDCA (4.50 ± 2.70 μmol/liter), and CLCA (1.70 ± 1.04 μmol/liter) were significantly higher than those in the mother (CCA 0.34 ± 0.17 μmol/liter; CCDCA 0.79 ± 0.34 μmol/liter; CLCA: 0.70 ± 0.30 μmol/liter; p <0.001); fetal serum levels of CDCA (0.46 ± 0.32 μmol/liter) and SLCG (0.15 ± 0.09 μmol/liter) were lower than in the mothers (CDCA 1.20 ± 0.80 μmol/liter, p <0.001; SLCG 0.40 ± 0.30 μmol/liter, p <0.01). There was no correlation between levels of BA and gestational age. Serum total protein and albumin concentrations were both reduced in 10 fetuses as compared with the mothers. These data support the concept of a state of physiologic cholestasis during development and suggest that placental transfer of primary BA occurs mostly in the fetal to maternal direction. This transfer could be facilitated by the reduced fetal plasma albumin concentration, since BA in free solution diffuse more easily through the placenta. There is evidence of lithocholic acid synthesis in the fetal liver, while deoxycholic acid appears to be mostly of maternal origin. Finally, sulfation of BA is poorly developed at this age of gestation.

AB - Serum concentrations of different bile acids (BA) were determined by radioimmunoassay in 56 human fetuses and mothers. Serum was obtained immediately after legal abortion, performed between the 14th and the 21st wk of gestation. Conjugated cholic (CCA) and chenodeoxycholic acid (CCDCA) concentrations were determined in 33 cases, conjugated lithocholic (CLCA) and deoxycholic acid (CDCA) in 20, and sulfolithocholyglycine (SLCG) in 15. In fetal blood, mean concentrations of CCA (0.80 ± 0.40 μmol/liter), CCDCA (4.50 ± 2.70 μmol/liter), and CLCA (1.70 ± 1.04 μmol/liter) were significantly higher than those in the mother (CCA 0.34 ± 0.17 μmol/liter; CCDCA 0.79 ± 0.34 μmol/liter; CLCA: 0.70 ± 0.30 μmol/liter; p <0.001); fetal serum levels of CDCA (0.46 ± 0.32 μmol/liter) and SLCG (0.15 ± 0.09 μmol/liter) were lower than in the mothers (CDCA 1.20 ± 0.80 μmol/liter, p <0.001; SLCG 0.40 ± 0.30 μmol/liter, p <0.01). There was no correlation between levels of BA and gestational age. Serum total protein and albumin concentrations were both reduced in 10 fetuses as compared with the mothers. These data support the concept of a state of physiologic cholestasis during development and suggest that placental transfer of primary BA occurs mostly in the fetal to maternal direction. This transfer could be facilitated by the reduced fetal plasma albumin concentration, since BA in free solution diffuse more easily through the placenta. There is evidence of lithocholic acid synthesis in the fetal liver, while deoxycholic acid appears to be mostly of maternal origin. Finally, sulfation of BA is poorly developed at this age of gestation.

UR - http://www.scopus.com/inward/record.url?scp=0021924997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021924997&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 227

EP - 231

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 2

ER -