Correlation between first-trimester uterine artery Doppler indices and maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A

Federico Prefumo, Silvana Canini, Valentina Casagrande, Daniela Pastorino, Pier Luigi Venturini, Pierangela De Biasio

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the correlation between first-trimester uterine artery Doppler measurements and maternal serum levels of free β-hCG and pregnancy-associated plasma protein A (PAPP-A). Design: Observational study. Setting: Teaching hospital. Patient(s): Four hundred thirty-three women at 10-14 weeks of gestation. Intervention(s): Doppler ultrasound of the uterine arteries. Fluorimetric immunoassays for free β-hCG and PAPP-A. Main Outcome Measure(s): Uterine artery mean resistance index (RI), pulsatility index (PI), and number of early diastolic notches. Maternal serum levels of free β-hCG and PAPP-A. Result(s): There were 401 uncomplicated pregnancies. In this group, free β-hCG and PAPP-A did not significantly correlate with uterine artery RI or PI (r values between -0.089 and 0.029, all nonsignificant). Free β-hCG and PAPP-A levels did not significantly change with the number of notches. Uterine artery resistance and PAPP-A levels were independently correlated with birth weight. Conclusion(s): Preliminary evidence suggests that first-trimester uterine artery Doppler measurements do not correlate with maternal serum levels of free β-hCG and PAPP-A. This may allow their combined use in multivariate screening for pregnancy complications.

Original languageEnglish
Pages (from-to)977-980
Number of pages4
JournalFertility and Sterility
Volume86
Issue number4
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Doppler
  • free β-hCG
  • impedance
  • PAPP-A
  • Uterine artery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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