Correlation between fractal behavior of HRV and neurohormonal and functional indexes in chronic heart failure

G. D. Addio, M. Cesarelli, M. Romano, A. Accardo, G. Corbi, R. Maestri, M. T. La Rovere, Paolo Bifulco, N. Ferrara, F. Rengo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Higher neurohormonal activation levels are known markers of severity and adverse prognosis in heart failure (HF) patients. Classical linear indexes of heart rate variability (HRV) have been shown to be associated with neurohormonal activation. Whether and to what extent non-linear properties of HRV, as expressed by the fractal dimension (FD) index, also reflect neurohormonal activation is not known. Aim of the study was to assess the association between FD, plasma norepinephrine (NPE) levels and functional parameters as compared to classical linear indexes of HRV in HF patients. Ninety-nine stable mild-to-moderate HF patients in sinus rhythm (age: 51±8 years, New York Heart Association class II-III, left ventricular ejection fraction [EF] 24±6%, maximal oxygen consumption [VO2max] during exercise tests 14±4 mL kg-1 min-1) were studied. Each patient underwent to a 24-hour Holter recording and to NPE assay within one week plasma, besides standard clinical and laboratory examinations. The standard deviation between normal to normal beats (SDNN) and the power in the low frequency band (LFP, 0.04-0.15 Hz) were computed on consecutive 5-min RR sequences. The FD was estimated by the Higuchi method. The association between HRV and neurohormonal and functional indexes was assessed by Spearman correlation coefficient. NPE, LFP, SDNN and FD were respectively (mean ± SD): 363±210 pg/l, 162±171 ms2, 36±15 ms and 1.6±0.1. Both SDNN and LFP showed a moderate but significant negative correlation with NPE levels (r=-0.37 and -0.44 respectively, p

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages53-56
Number of pages4
Volume29
DOIs
Publication statusPublished - 2010
Event12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 - Chalkidiki, Greece
Duration: May 27 2010May 30 2010

Other

Other12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010
CountryGreece
CityChalkidiki
Period5/27/105/30/10

Keywords

  • chronic heart failure
  • fractal dimension
  • HRV

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

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