Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine: A case-control study

Anna Ambrosini, Ennio Iezzi, Armando Perrotta, Aliaksei Kisialiou, Andrea Nardella, Alfredo Berardelli, Francesco Pierelli, Jean Schoenen

Research output: Contribution to journalArticle

Abstract

Introduction In migraine most studies report an interictal deficit of habituation of visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched for a possible correlation between VEP-hab and PT in migraine patients and healthy controls to test whether they reflect the same pathophysiological abnormality. Methods We assessed PT and VEP-hab measured as the percentage change of N1/P1 amplitude over six blocks of 100 responses in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura (MO) between attacks. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman's correlation. Results In MO patients VEP-hab was reduced compared to HV (p = 0.001), while PT were not significantly different between HV and MO. There was no correlation between PT and VEP-hab in either group of participants. Conclusions We confirm that in interictal migraine VEP habituation is deficient, but magnetophosphene threshold normal. VEP-hab and PT were not correlated with each other in healthy controls or in migraineurs. This finding suggests that they index different facets of cortical excitability in migraine, i.e. a punctual normal measure of the cortical activation threshold for PT and a dynamic response pattern to repeated stimuli for VEP habituation.

Original languageEnglish
Pages (from-to)258-264
Number of pages7
JournalCephalalgia
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Visual Evoked Potentials
Migraine Disorders
Case-Control Studies
Healthy Volunteers
Phosphenes
Transcranial Magnetic Stimulation
Nonparametric Statistics
Epilepsy

Keywords

  • cortical excitability
  • habituation
  • magnetophosphene threshold
  • Migraine
  • visual-evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine : A case-control study. / Ambrosini, Anna; Iezzi, Ennio; Perrotta, Armando; Kisialiou, Aliaksei; Nardella, Andrea; Berardelli, Alfredo; Pierelli, Francesco; Schoenen, Jean.

In: Cephalalgia, Vol. 36, No. 3, 01.03.2016, p. 258-264.

Research output: Contribution to journalArticle

@article{3559f49fdcce4ae0b5e3912991ed7788,
title = "Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine: A case-control study",
abstract = "Introduction In migraine most studies report an interictal deficit of habituation of visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched for a possible correlation between VEP-hab and PT in migraine patients and healthy controls to test whether they reflect the same pathophysiological abnormality. Methods We assessed PT and VEP-hab measured as the percentage change of N1/P1 amplitude over six blocks of 100 responses in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura (MO) between attacks. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman's correlation. Results In MO patients VEP-hab was reduced compared to HV (p = 0.001), while PT were not significantly different between HV and MO. There was no correlation between PT and VEP-hab in either group of participants. Conclusions We confirm that in interictal migraine VEP habituation is deficient, but magnetophosphene threshold normal. VEP-hab and PT were not correlated with each other in healthy controls or in migraineurs. This finding suggests that they index different facets of cortical excitability in migraine, i.e. a punctual normal measure of the cortical activation threshold for PT and a dynamic response pattern to repeated stimuli for VEP habituation.",
keywords = "cortical excitability, habituation, magnetophosphene threshold, Migraine, visual-evoked potentials",
author = "Anna Ambrosini and Ennio Iezzi and Armando Perrotta and Aliaksei Kisialiou and Andrea Nardella and Alfredo Berardelli and Francesco Pierelli and Jean Schoenen",
year = "2016",
month = "3",
day = "1",
doi = "10.1177/0333102415590241",
language = "English",
volume = "36",
pages = "258--264",
journal = "Cephalalgia",
issn = "0333-1024",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Correlation between habituation of visual-evoked potentials and magnetophosphene thresholds in migraine

T2 - A case-control study

AU - Ambrosini, Anna

AU - Iezzi, Ennio

AU - Perrotta, Armando

AU - Kisialiou, Aliaksei

AU - Nardella, Andrea

AU - Berardelli, Alfredo

AU - Pierelli, Francesco

AU - Schoenen, Jean

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Introduction In migraine most studies report an interictal deficit of habituation of visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched for a possible correlation between VEP-hab and PT in migraine patients and healthy controls to test whether they reflect the same pathophysiological abnormality. Methods We assessed PT and VEP-hab measured as the percentage change of N1/P1 amplitude over six blocks of 100 responses in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura (MO) between attacks. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman's correlation. Results In MO patients VEP-hab was reduced compared to HV (p = 0.001), while PT were not significantly different between HV and MO. There was no correlation between PT and VEP-hab in either group of participants. Conclusions We confirm that in interictal migraine VEP habituation is deficient, but magnetophosphene threshold normal. VEP-hab and PT were not correlated with each other in healthy controls or in migraineurs. This finding suggests that they index different facets of cortical excitability in migraine, i.e. a punctual normal measure of the cortical activation threshold for PT and a dynamic response pattern to repeated stimuli for VEP habituation.

AB - Introduction In migraine most studies report an interictal deficit of habituation of visual-evoked potentials (VEP-hab) and reduced thresholds for phosphene induction (PT) by transcranial magnetic stimulation (TMS). We searched for a possible correlation between VEP-hab and PT in migraine patients and healthy controls to test whether they reflect the same pathophysiological abnormality. Methods We assessed PT and VEP-hab measured as the percentage change of N1/P1 amplitude over six blocks of 100 responses in 15 healthy volunteers (HV) and in 13 episodic migraineurs without aura (MO) between attacks. Results were compared using Mann-Whitney U test. Interrelationships were examined using Spearman's correlation. Results In MO patients VEP-hab was reduced compared to HV (p = 0.001), while PT were not significantly different between HV and MO. There was no correlation between PT and VEP-hab in either group of participants. Conclusions We confirm that in interictal migraine VEP habituation is deficient, but magnetophosphene threshold normal. VEP-hab and PT were not correlated with each other in healthy controls or in migraineurs. This finding suggests that they index different facets of cortical excitability in migraine, i.e. a punctual normal measure of the cortical activation threshold for PT and a dynamic response pattern to repeated stimuli for VEP habituation.

KW - cortical excitability

KW - habituation

KW - magnetophosphene threshold

KW - Migraine

KW - visual-evoked potentials

UR - http://www.scopus.com/inward/record.url?scp=84959290498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959290498&partnerID=8YFLogxK

U2 - 10.1177/0333102415590241

DO - 10.1177/0333102415590241

M3 - Article

AN - SCOPUS:84959290498

VL - 36

SP - 258

EP - 264

JO - Cephalalgia

JF - Cephalalgia

SN - 0333-1024

IS - 3

ER -