Correlation between histochemically assessed hormonal receptor content and clinical course in breast cancer: Presentation of 1,005 cases

Ornella Gottardi, Claudia Baiocchi, Massimo Ferrari, Luigina Franchi, Marcello Gambacorta, Giuseppe Landonio, Nina Pinna, Enrico Ghislandi

Research output: Contribution to journalArticle


Lee’s histochemical method was used to assess hormonal receptors in 1,005 patients with breast cancer. Patients were from 8 oncological departments in northern Italy. The group was subdivided into four subgroups in relation to menopausal status and presence or absence of axillary node metastasis. Overall survival (OS) and disease-free survival (DFS) were analysed in all subgroups in relation to receptorial status. We observed: (1) when hormonal receptors are present, OS and DFS are longer in all subgroups; (2) the presence of hormonal receptors influences favourably both DFS and OS, but it seems to play a more important role for DFS; (3) the positive receptorial status is a better prognostic factor in groups without axillary node metastasis, especially in premenopausal patients. We conclude that the histochemical assessment of hormonal receptors is a valid method for the prognostic evaluation of patients with breast cancer.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
Issue number3
Publication statusPublished - 1991



  • Breast cancer
  • Histochemical assessment
  • Hormonal receptors
  • Prognostic value

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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