Forty-one patients with low grade cervical dysplasia (CIN I) were examined using a polymerase chain reaction to establish the relationship between human papillomavirus (HPV) specific genome and progressive potential of intra-epithelial dysplasia. Thirty-one (75 per cent) of patients had human papillomavirus sequences. HPV 6/11 was detected in 19 cases, while 12 had the 'high risk' HPV type 16. Twenty-seven patients were monitored for 1 year without treatment to study the progressive potential of the cervical lesion. We observed that patients carrying HPV 16 change more readily to high grade dysplasia (CIN II or HI) than patients with (or without) HPV 6/11.
ASJC Scopus subject areas
- Obstetrics and Gynaecology