Correlation between left atrial size, prothrombotic state and markers of endothelial dysfunction in patients with lone chronic nonrheumatic atrial fibrillation

Sergio Mondillo, Laura Sabatini, Eustachio Agricola, Tiziana Ammaturo, Francesco Guerrini, Riccardo Barbati, Monica Pastore, Daniela Fineschi, Renato Nami

Research output: Contribution to journalArticlepeer-review

Abstract

Atrial fibrillation is associated with a prothrombotic state and endothelial dysfunction. To understand whether the prothrombotic state was correlated with endothelial dysfunction and whether the latter was related to atrial dimension (endocardial damage), we studied systemic hemocoagulative activity and markers of endothelial dysfunction in 45 patients with chronic nonrheumatic atrial fibrillation and in 35 controls. We assessed fibrinogen, antithrombin III, protein C, markers of platelet activation (platelet factor 4 and β-thromboglobulin) as markers of fibrinolysis, and D-dimer, tissue plasminogen activator, plasminogen activator inhibitor, von Willebrand's factor and soluble thrombomodulin as endothelial dysfunction. Plasma fibrinogen (P

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalInternational Journal of Cardiology
Volume75
Issue number2-3
DOIs
Publication statusPublished - Sep 15 2000

Keywords

  • Endothelial dysfunction
  • Hypercoagulability
  • Left atrium
  • Nonrheumatic atrial fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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