Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer

Maria Ornella Nicoletto, Donato Nitti, Luigi Pescarini, Francesco Corbetti, Roberto Mencarelli, Alessandro Cappetta, Alessandra Galligioni, Claudia Pogliani, Alberto Marchet, Fernando Bozza, Cristina Ghiotto, Luciano Griggio, Giorgio Zavagno, Martin Edward Donach, Cosimo Di Maggio

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim. To evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer. Materials and methods. Twenty-six patients entered a phase II study of neoadjuvant chemotherapy, undergoing bilateral breast magnetic resonance imaging before therapy and before surgery. Tumor response was classified using RECIST criteria, using tumor size at magnetic resonance imaging. The latter was then compared to residue found at histopathological examination. Results. Magnetic resonance imaging showed 6 (23%) complete responses, 17 (65%) partial responses, 3 (11.5%) disease stabilizations and no disease progressions. Twenty-three tumors (88.5%) were considered responsive and 3 (11.5%) unresponsive. Pathological tumor response was: 6 complete responses (23%), 17 partial responses (65%), 2 stable disease (8%), 1 progression (4%). When results of the preoperative magnetic resonance imaging were compared to pathological tumor response, magnetic resonance imaging overestimated tumor size in 12 cases (46%) and underestimated it in 9 (35%). However, preoperative magnetic resonance imaging failed to detect invasive tumor in 2 false-negative cases (8%), 1 of which was multifocal. Mastectomy was performed in 12 cases: 1 case of disease progression even though the neoplasm appeared smaller at magnetic resonance imaging, 3 cases with stable disease, and 4 cases with T3 or T4 disease. The 9 th patient was T2N2 with initial retroareolar disease and negative magnetic resonance imaging after chemotherapy. The 10 th patient, affected by lobular cancer, was in partial remission but was T3N1. The 11 th patient was 57 years old but was not interested in conservative surgery. The 12 th patient requested bilateral prophylactic mastectomy due to her positive family history of breast cancer. Conclusions. Magnetic resonance imaging of the breast allowed conservative surgery in 54% of the patients. This low value is primarily due to overestimation of tumor size, with a negative predictive value of 67% in our population. However, surgeons were able to choose conservative surgery with relative safety in cases of small residual disease.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalTumori
Volume94
Issue number4
Publication statusPublished - Jul 2008

Fingerprint

Magnetic Resonance Imaging
Breast Neoplasms
Drug Therapy
Neoplasms
Disease Progression
Breast
Mastectomy
Safety
Population

Keywords

  • Breast cancer
  • Chemotherapy
  • Magnetic resonance imaging
  • Neoadjuvant
  • Predictive value
  • Tumor response

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nicoletto, M. O., Nitti, D., Pescarini, L., Corbetti, F., Mencarelli, R., Cappetta, A., ... Di Maggio, C. (2008). Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer. Tumori, 94(4), 481-488.

Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer. / Nicoletto, Maria Ornella; Nitti, Donato; Pescarini, Luigi; Corbetti, Francesco; Mencarelli, Roberto; Cappetta, Alessandro; Galligioni, Alessandra; Pogliani, Claudia; Marchet, Alberto; Bozza, Fernando; Ghiotto, Cristina; Griggio, Luciano; Zavagno, Giorgio; Donach, Martin Edward; Di Maggio, Cosimo.

In: Tumori, Vol. 94, No. 4, 07.2008, p. 481-488.

Research output: Contribution to journalArticle

Nicoletto, MO, Nitti, D, Pescarini, L, Corbetti, F, Mencarelli, R, Cappetta, A, Galligioni, A, Pogliani, C, Marchet, A, Bozza, F, Ghiotto, C, Griggio, L, Zavagno, G, Donach, ME & Di Maggio, C 2008, 'Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer', Tumori, vol. 94, no. 4, pp. 481-488.
Nicoletto, Maria Ornella ; Nitti, Donato ; Pescarini, Luigi ; Corbetti, Francesco ; Mencarelli, Roberto ; Cappetta, Alessandro ; Galligioni, Alessandra ; Pogliani, Claudia ; Marchet, Alberto ; Bozza, Fernando ; Ghiotto, Cristina ; Griggio, Luciano ; Zavagno, Giorgio ; Donach, Martin Edward ; Di Maggio, Cosimo. / Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer. In: Tumori. 2008 ; Vol. 94, No. 4. pp. 481-488.
@article{17f57844aaca446e83ae95d3f56bbac3,
title = "Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer",
abstract = "Aim. To evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer. Materials and methods. Twenty-six patients entered a phase II study of neoadjuvant chemotherapy, undergoing bilateral breast magnetic resonance imaging before therapy and before surgery. Tumor response was classified using RECIST criteria, using tumor size at magnetic resonance imaging. The latter was then compared to residue found at histopathological examination. Results. Magnetic resonance imaging showed 6 (23{\%}) complete responses, 17 (65{\%}) partial responses, 3 (11.5{\%}) disease stabilizations and no disease progressions. Twenty-three tumors (88.5{\%}) were considered responsive and 3 (11.5{\%}) unresponsive. Pathological tumor response was: 6 complete responses (23{\%}), 17 partial responses (65{\%}), 2 stable disease (8{\%}), 1 progression (4{\%}). When results of the preoperative magnetic resonance imaging were compared to pathological tumor response, magnetic resonance imaging overestimated tumor size in 12 cases (46{\%}) and underestimated it in 9 (35{\%}). However, preoperative magnetic resonance imaging failed to detect invasive tumor in 2 false-negative cases (8{\%}), 1 of which was multifocal. Mastectomy was performed in 12 cases: 1 case of disease progression even though the neoplasm appeared smaller at magnetic resonance imaging, 3 cases with stable disease, and 4 cases with T3 or T4 disease. The 9 th patient was T2N2 with initial retroareolar disease and negative magnetic resonance imaging after chemotherapy. The 10 th patient, affected by lobular cancer, was in partial remission but was T3N1. The 11 th patient was 57 years old but was not interested in conservative surgery. The 12 th patient requested bilateral prophylactic mastectomy due to her positive family history of breast cancer. Conclusions. Magnetic resonance imaging of the breast allowed conservative surgery in 54{\%} of the patients. This low value is primarily due to overestimation of tumor size, with a negative predictive value of 67{\%} in our population. However, surgeons were able to choose conservative surgery with relative safety in cases of small residual disease.",
keywords = "Breast cancer, Chemotherapy, Magnetic resonance imaging, Neoadjuvant, Predictive value, Tumor response",
author = "Nicoletto, {Maria Ornella} and Donato Nitti and Luigi Pescarini and Francesco Corbetti and Roberto Mencarelli and Alessandro Cappetta and Alessandra Galligioni and Claudia Pogliani and Alberto Marchet and Fernando Bozza and Cristina Ghiotto and Luciano Griggio and Giorgio Zavagno and Donach, {Martin Edward} and {Di Maggio}, Cosimo",
year = "2008",
month = "7",
language = "English",
volume = "94",
pages = "481--488",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Correlation between magnetic resonance imaging and histopathological tumor response after neoadjuvant chemotherapy in breast cancer

AU - Nicoletto, Maria Ornella

AU - Nitti, Donato

AU - Pescarini, Luigi

AU - Corbetti, Francesco

AU - Mencarelli, Roberto

AU - Cappetta, Alessandro

AU - Galligioni, Alessandra

AU - Pogliani, Claudia

AU - Marchet, Alberto

AU - Bozza, Fernando

AU - Ghiotto, Cristina

AU - Griggio, Luciano

AU - Zavagno, Giorgio

AU - Donach, Martin Edward

AU - Di Maggio, Cosimo

PY - 2008/7

Y1 - 2008/7

N2 - Aim. To evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer. Materials and methods. Twenty-six patients entered a phase II study of neoadjuvant chemotherapy, undergoing bilateral breast magnetic resonance imaging before therapy and before surgery. Tumor response was classified using RECIST criteria, using tumor size at magnetic resonance imaging. The latter was then compared to residue found at histopathological examination. Results. Magnetic resonance imaging showed 6 (23%) complete responses, 17 (65%) partial responses, 3 (11.5%) disease stabilizations and no disease progressions. Twenty-three tumors (88.5%) were considered responsive and 3 (11.5%) unresponsive. Pathological tumor response was: 6 complete responses (23%), 17 partial responses (65%), 2 stable disease (8%), 1 progression (4%). When results of the preoperative magnetic resonance imaging were compared to pathological tumor response, magnetic resonance imaging overestimated tumor size in 12 cases (46%) and underestimated it in 9 (35%). However, preoperative magnetic resonance imaging failed to detect invasive tumor in 2 false-negative cases (8%), 1 of which was multifocal. Mastectomy was performed in 12 cases: 1 case of disease progression even though the neoplasm appeared smaller at magnetic resonance imaging, 3 cases with stable disease, and 4 cases with T3 or T4 disease. The 9 th patient was T2N2 with initial retroareolar disease and negative magnetic resonance imaging after chemotherapy. The 10 th patient, affected by lobular cancer, was in partial remission but was T3N1. The 11 th patient was 57 years old but was not interested in conservative surgery. The 12 th patient requested bilateral prophylactic mastectomy due to her positive family history of breast cancer. Conclusions. Magnetic resonance imaging of the breast allowed conservative surgery in 54% of the patients. This low value is primarily due to overestimation of tumor size, with a negative predictive value of 67% in our population. However, surgeons were able to choose conservative surgery with relative safety in cases of small residual disease.

AB - Aim. To evaluate the accuracy of magnetic resonance imaging in assessing tumor response following neoadjuvant chemotherapy in patients with locally advanced breast cancer. Materials and methods. Twenty-six patients entered a phase II study of neoadjuvant chemotherapy, undergoing bilateral breast magnetic resonance imaging before therapy and before surgery. Tumor response was classified using RECIST criteria, using tumor size at magnetic resonance imaging. The latter was then compared to residue found at histopathological examination. Results. Magnetic resonance imaging showed 6 (23%) complete responses, 17 (65%) partial responses, 3 (11.5%) disease stabilizations and no disease progressions. Twenty-three tumors (88.5%) were considered responsive and 3 (11.5%) unresponsive. Pathological tumor response was: 6 complete responses (23%), 17 partial responses (65%), 2 stable disease (8%), 1 progression (4%). When results of the preoperative magnetic resonance imaging were compared to pathological tumor response, magnetic resonance imaging overestimated tumor size in 12 cases (46%) and underestimated it in 9 (35%). However, preoperative magnetic resonance imaging failed to detect invasive tumor in 2 false-negative cases (8%), 1 of which was multifocal. Mastectomy was performed in 12 cases: 1 case of disease progression even though the neoplasm appeared smaller at magnetic resonance imaging, 3 cases with stable disease, and 4 cases with T3 or T4 disease. The 9 th patient was T2N2 with initial retroareolar disease and negative magnetic resonance imaging after chemotherapy. The 10 th patient, affected by lobular cancer, was in partial remission but was T3N1. The 11 th patient was 57 years old but was not interested in conservative surgery. The 12 th patient requested bilateral prophylactic mastectomy due to her positive family history of breast cancer. Conclusions. Magnetic resonance imaging of the breast allowed conservative surgery in 54% of the patients. This low value is primarily due to overestimation of tumor size, with a negative predictive value of 67% in our population. However, surgeons were able to choose conservative surgery with relative safety in cases of small residual disease.

KW - Breast cancer

KW - Chemotherapy

KW - Magnetic resonance imaging

KW - Neoadjuvant

KW - Predictive value

KW - Tumor response

UR - http://www.scopus.com/inward/record.url?scp=54749154015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54749154015&partnerID=8YFLogxK

M3 - Article

VL - 94

SP - 481

EP - 488

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 4

ER -