Correlation between MRI findings and long-term outcome in patients with severe brain trauma

A. Pierallini, P. Pantano, L. M. Fantozzi, M. Bonamini, R. Vichi, R. Zylberman, F. Pisarri, C. Colonnese, L. Bozzao

Research output: Contribution to journalArticlepeer-review


Our aim was to relate MRI findings in patients with severe traumatic brain injury (TBI) to clinical severity and long-term outcome. We studied 37 patients with severe TBI, who were submitted to clinical assessment for disability and cognition and to MRI 60-90 days after trauma. Clinical assdssment was also performed 3, 6 and 12 months later. The number and volume of lesions in various cerebral structures were calculated semiautomatically from FLAIR and fast field-echo images. Possible correlations between total and regional lesion volume and clinical deficits were then investigated. The frontal and temporal lobes were most frequently involved. Total lesion volume on FLAIR images correlated significantly with clinical outcome, whereas that on FFE images did not. Regional analysis showed that FLAIR lesion volume in the corpus callosum correlated significantly with scores on disability and cognition scales at the first clinical assessment. FLAIR lesion volume in the frontal lobes correlated significantly with clinical scores 1 year later.

Original languageEnglish
Pages (from-to)860-867
Number of pages8
Issue number12
Publication statusPublished - 2000


  • Magnetic resonance imaging
  • Pulse sequences
  • Traumatic brain injury

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

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