Correlation between multimodal evoked potentials and magnetic resonance imaging in multiple sclerosis

G. Comi, V. Martinelli, S. Medaglini, T. Locatelli, M. Filippi, N. Canal, F. Triulzi, A. Del Maschio

Research output: Contribution to journalArticle

Abstract

Sixty multiple sclerosis (MS) patients (33 definite, 13 probale and 14 suspected were investigated by computed tomography (CT), magnetic resonance imaging (MRI), multimodality evoked potentials (EPs) and cerebrospinal fluid (CSF) electrophoresis. MRI abnormalities were found in 50 cases, while at least one abnormal evoked potential was detected in each of 52 cases. Brain-stem auditory evoked potentials were more sensitive than MRI for the detection of brainstem involvement. All the patients with oligoclonal bands had abnormal MRI and none of the patients with normal MRI had oligoclonal bands in the CSF. The number and the extent of MRI lesions were significantly correlated with the duration of disease and with the degree of disability. Our observations stress the importance of the combined use of MRI and EPs in detecting silent CNS lesions in MS patients.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalJournal of Neurology
Volume236
Issue number1
DOIs
Publication statusPublished - Jan 1989

Keywords

  • Diagnosis
  • Electrophysiological tests
  • Magnetic resonance imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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