Correlation between peri-operative serum lactate levels and outcome in pancreatic resection for pancreatic cancer, preliminary report

Salvatore Gruttadauria, I. R. Marino, C. H. Vitale, L. Mandala, V. L. Scott, C. Doria

Research output: Contribution to journalArticle

Abstract

This study was undertaken in order to verify if peri-operative serum lactate level changes, resulting from manipulation of the splanchnic circulation during pancreatectomy, reflected clinical outcome in twenty patients (9 males - 11 females age 33 to 76) operated for pancreatic cancer. Lactate levels were evaluated at the beginning of the procedure (TO), after surgical manipulation before pancreatic resection (T1), after resection (T2), and 24 hours post-op. (T3). Furthermore, to highlight possible hemodynamic instability that could contribute to altered lactate clearance, mean arterial pressure (MAP) and central venous pressure (CVP) were continuously monitored during the study period. Peri-operative mortality within 60 days after surgery, Intensive Care Unit (ICU) length of stay, and peri-operative complications were the main indicators investigated in order to evaluate the impact of serial lactate levels in this patient population. Hyperlactatemia observed peri-operatively during pancreatic resection for cancer is significantly correlated with peri-operative mortality and also with longer ICU length of stay. Though, due to the relatively small number of the patients, more extensive investigation is needed in order to confirm such interesting preliminary data.

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Volume21
Issue number4
Publication statusPublished - Dec 2002

Keywords

  • Lactate
  • Pancreatic cancer
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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