Abstract
CA 72-4 serum marker has been shown to be one of the most specific and sensitive markers for monitoring gastric cancer. In the present study we evaluated the correlation between CA 72-4, CA 19-9 and CEA serum levels, and tumor size and lymph node involvement in gastric carcinoma patients. One-hundred sixty-one patients with primary or recurrent gastric carcinoma were studied. Elevated CA 72-4, CA 19-9, and CEA serum levels were found in 42.2%, 32.3% and 24.2%, respectively. As previously shown, the combination of CA 72-4 and CA 19-9 increased positive samples to 56.5%, while the addition of CEA did not further improve this percentage. Unlike what has been previously published, none of the markers showed a significant correlation with serosal involvement. In fact, elevated serum levels were observed for the three markers in a very low percentage of cases either in T1-T2N0 or T3-T4N0 patients. In contrast, CA 72-4 showed a highly significant correlation with lymph node involvement: T1-T4N0 patients had positive CA 72-4 levels in 5 out of 37 (13.5%), while T1-T4N1 in 12 out of 32 (37.5%), and T1-T4N2 in 20 out of 40 (50%) (p <0.003). CA 19-9 and CEA serum levels were not significantly correlated. Since the presence of lymph node metastases is considered a negative prognostic factor, these results suggest that the measurement of CA 72-4 serum levels may be an important parameter in the diagnosis and clinical follow-up of patients with gastric carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 2409-2413 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 13 |
| Issue number | 6 B |
| Publication status | Published - 1993 |
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Keywords
- Gastric cancer
- Lymph node and serosal involvement
- Monoclonal antibodies
- Serum tumor markers
- Tumor-associated glycoprotein-72 CA 72-4 assay
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Correlation between positive CA 72-4 serum levels and lymph node involvement in patients with gastric carcinoma. / Guadagni, F.; Roselli, M.; Cosimelli, M.; Ferroni, P.; Spila, A.; Casaldi, V.; Cavaliere, F.; Carlini, M.; Garofalo, A.; Rinaldi, G.; Santoro, E.; Greiner, J. W.; Schlom, J.
In: Anticancer Research, Vol. 13, No. 6 B, 1993, p. 2409-2413.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between positive CA 72-4 serum levels and lymph node involvement in patients with gastric carcinoma
AU - Guadagni, F.
AU - Roselli, M.
AU - Cosimelli, M.
AU - Ferroni, P.
AU - Spila, A.
AU - Casaldi, V.
AU - Cavaliere, F.
AU - Carlini, M.
AU - Garofalo, A.
AU - Rinaldi, G.
AU - Santoro, E.
AU - Greiner, J. W.
AU - Schlom, J.
PY - 1993
Y1 - 1993
N2 - CA 72-4 serum marker has been shown to be one of the most specific and sensitive markers for monitoring gastric cancer. In the present study we evaluated the correlation between CA 72-4, CA 19-9 and CEA serum levels, and tumor size and lymph node involvement in gastric carcinoma patients. One-hundred sixty-one patients with primary or recurrent gastric carcinoma were studied. Elevated CA 72-4, CA 19-9, and CEA serum levels were found in 42.2%, 32.3% and 24.2%, respectively. As previously shown, the combination of CA 72-4 and CA 19-9 increased positive samples to 56.5%, while the addition of CEA did not further improve this percentage. Unlike what has been previously published, none of the markers showed a significant correlation with serosal involvement. In fact, elevated serum levels were observed for the three markers in a very low percentage of cases either in T1-T2N0 or T3-T4N0 patients. In contrast, CA 72-4 showed a highly significant correlation with lymph node involvement: T1-T4N0 patients had positive CA 72-4 levels in 5 out of 37 (13.5%), while T1-T4N1 in 12 out of 32 (37.5%), and T1-T4N2 in 20 out of 40 (50%) (p <0.003). CA 19-9 and CEA serum levels were not significantly correlated. Since the presence of lymph node metastases is considered a negative prognostic factor, these results suggest that the measurement of CA 72-4 serum levels may be an important parameter in the diagnosis and clinical follow-up of patients with gastric carcinoma.
AB - CA 72-4 serum marker has been shown to be one of the most specific and sensitive markers for monitoring gastric cancer. In the present study we evaluated the correlation between CA 72-4, CA 19-9 and CEA serum levels, and tumor size and lymph node involvement in gastric carcinoma patients. One-hundred sixty-one patients with primary or recurrent gastric carcinoma were studied. Elevated CA 72-4, CA 19-9, and CEA serum levels were found in 42.2%, 32.3% and 24.2%, respectively. As previously shown, the combination of CA 72-4 and CA 19-9 increased positive samples to 56.5%, while the addition of CEA did not further improve this percentage. Unlike what has been previously published, none of the markers showed a significant correlation with serosal involvement. In fact, elevated serum levels were observed for the three markers in a very low percentage of cases either in T1-T2N0 or T3-T4N0 patients. In contrast, CA 72-4 showed a highly significant correlation with lymph node involvement: T1-T4N0 patients had positive CA 72-4 levels in 5 out of 37 (13.5%), while T1-T4N1 in 12 out of 32 (37.5%), and T1-T4N2 in 20 out of 40 (50%) (p <0.003). CA 19-9 and CEA serum levels were not significantly correlated. Since the presence of lymph node metastases is considered a negative prognostic factor, these results suggest that the measurement of CA 72-4 serum levels may be an important parameter in the diagnosis and clinical follow-up of patients with gastric carcinoma.
KW - Gastric cancer
KW - Lymph node and serosal involvement
KW - Monoclonal antibodies
KW - Serum tumor markers
KW - Tumor-associated glycoprotein-72 CA 72-4 assay
UR - http://www.scopus.com/inward/record.url?scp=0027848621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027848621&partnerID=8YFLogxK
M3 - Article
C2 - 8135475
AN - SCOPUS:0027848621
VL - 13
SP - 2409
EP - 2413
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6 B
ER -