Correlation between salivary and serum oxidized LDL levels: A pilot study on overweight/obese subjects

R. De Giuseppe, G. Cossellu, L. Vigna, F. Dicorato, C. De Vita, G. Venturelli, F. Bamonti, R. Maiavacca, G. Farronato

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Saliva contains a variety of substances and could be functionally equivalent to serum in reflecting the physiological state of the body, including metabolic variations. Salivary samples are non-invasive, safe, and easier to handle than serum. Oxidized LDL cholesterol (oxLDL) is an additional cardiovascular risk factor playing an important role in atheromatous plaque formation; overweight/obese subjects present an increase in oxLDL concentrations. The aims of the study were to assess oxLDL salivary levels, if detectable, and to verify their possible correlation with serum in overweight/obese subjects. Methods: Thirty-five consecutive overweight/obese subjects and 10 normal weight controls were enrolled. Serum and salivary oxLDL levels were measured by a commercial enzyme-linked-immunosorbent assay (ELISA method). Results: oxLDL levels were detectable in salivary samples and correlated (P = 0.001) with serum levels. Overweight/obese subjects showed serum and salivary oxLDL levels higher than controls (P = 0.000 and P = 0.022, respectively). Conclusions: Our study showed the presence of oxLDL in salivary samples and highlighted a correlation between salivary oxLDL levels and their counterpart in serum. Moreover, salivary oxLDL levels were higher in overweight/obese subjects than in controls. Therefore, a salivary sample could be functionally equivalent to serum in monitoring cardiovascular risk in overweight/obese subjects.

Original languageEnglish
Pages (from-to)884-887
Number of pages4
JournalJournal of Oral Pathology and Medicine
Volume44
Issue number10
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

LDL Cholesterol
Serum
Enzyme-Linked Immunosorbent Assay
oxidized low density lipoprotein
Atherosclerotic Plaques
Saliva
Weights and Measures

Keywords

  • Obesity
  • Oxidized LDL cholesterol
  • Periodontitis
  • Salivary samples

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oral Surgery
  • Periodontics

Cite this

Correlation between salivary and serum oxidized LDL levels : A pilot study on overweight/obese subjects. / De Giuseppe, R.; Cossellu, G.; Vigna, L.; Dicorato, F.; De Vita, C.; Venturelli, G.; Bamonti, F.; Maiavacca, R.; Farronato, G.

In: Journal of Oral Pathology and Medicine, Vol. 44, No. 10, 01.11.2015, p. 884-887.

Research output: Contribution to journalArticle

De Giuseppe, R. ; Cossellu, G. ; Vigna, L. ; Dicorato, F. ; De Vita, C. ; Venturelli, G. ; Bamonti, F. ; Maiavacca, R. ; Farronato, G. / Correlation between salivary and serum oxidized LDL levels : A pilot study on overweight/obese subjects. In: Journal of Oral Pathology and Medicine. 2015 ; Vol. 44, No. 10. pp. 884-887.
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AU - De Vita, C.

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