Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission

J. R. Fiore, M. Jansson, G. Scarlatti, G. Angarano, S. Lo Caputo, G. Buccoliero, P. Rossi, E. M. Fenyo, G. Pastore

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate the correlation between seroreactivity to peptides corresponding to the V3 loop of the major envelope glycoprotein from different HIV-1 strains and the risk of heterosexual HIV-1 transmission. Methods: Sera from 39 infected individuals (16 transmitters and 23 non-transmitters) were tested for reactivity against synthetic peptides representing sequences of the V3 loop apex from HIV-1 strains MN, SC, WMJ2, RF and IIIB. Results: A skewed distribution in seroreactivity to RF and IIIB peptides was observed between the two groups: reactivity was more prevalent in sera from non-transmitting than from transmitting individuals. Reactivity to the MN, SC and WMJ2 peptides was very frequent and there were no differences between the two groups. Conclusion: These data suggest that antibodies reactive with a larger set of V3 apex peptides (i.e., cross-reactive antibodies) could play a role in the prevention of heterosexual transmission.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalAIDS (London, England)
Issue number1
Publication statusPublished - 1993


  • Heterosexual transmission
  • HIV-1
  • V3 loop peptides

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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