Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission

J. R. Fiore, M. Jansson, G. Scarlatti, G. Angarano, S. Lo Caputo, G. Buccoliero, P. Rossi, E. M. Fenyo, G. Pastore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To evaluate the correlation between seroreactivity to peptides corresponding to the V3 loop of the major envelope glycoprotein from different HIV-1 strains and the risk of heterosexual HIV-1 transmission. Methods: Sera from 39 infected individuals (16 transmitters and 23 non-transmitters) were tested for reactivity against synthetic peptides representing sequences of the V3 loop apex from HIV-1 strains MN, SC, WMJ2, RF and IIIB. Results: A skewed distribution in seroreactivity to RF and IIIB peptides was observed between the two groups: reactivity was more prevalent in sera from non-transmitting than from transmitting individuals. Reactivity to the MN, SC and WMJ2 peptides was very frequent and there were no differences between the two groups. Conclusion: These data suggest that antibodies reactive with a larger set of V3 apex peptides (i.e., cross-reactive antibodies) could play a role in the prevention of heterosexual transmission.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalAIDS (London, England)
Volume7
Issue number1
Publication statusPublished - 1993

Fingerprint

Heterosexuality
Peptides
HIV-1
Antibodies
Serum
Glycoproteins
HIV envelope protein gp120 (305-321)

Keywords

  • Heterosexual transmission
  • HIV-1
  • V3 loop peptides

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Fiore, J. R., Jansson, M., Scarlatti, G., Angarano, G., Lo Caputo, S., Buccoliero, G., ... Pastore, G. (1993). Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission. AIDS (London, England), 7(1), 29-31.

Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission. / Fiore, J. R.; Jansson, M.; Scarlatti, G.; Angarano, G.; Lo Caputo, S.; Buccoliero, G.; Rossi, P.; Fenyo, E. M.; Pastore, G.

In: AIDS (London, England), Vol. 7, No. 1, 1993, p. 29-31.

Research output: Contribution to journalArticle

Fiore, JR, Jansson, M, Scarlatti, G, Angarano, G, Lo Caputo, S, Buccoliero, G, Rossi, P, Fenyo, EM & Pastore, G 1993, 'Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission', AIDS (London, England), vol. 7, no. 1, pp. 29-31.
Fiore, J. R. ; Jansson, M. ; Scarlatti, G. ; Angarano, G. ; Lo Caputo, S. ; Buccoliero, G. ; Rossi, P. ; Fenyo, E. M. ; Pastore, G. / Correlation between seroreactivity to HIV-1 V3 loop peptides and male-to-female heterosexual transmission. In: AIDS (London, England). 1993 ; Vol. 7, No. 1. pp. 29-31.
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AU - Jansson, M.

AU - Scarlatti, G.

AU - Angarano, G.

AU - Lo Caputo, S.

AU - Buccoliero, G.

AU - Rossi, P.

AU - Fenyo, E. M.

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AB - Objective: To evaluate the correlation between seroreactivity to peptides corresponding to the V3 loop of the major envelope glycoprotein from different HIV-1 strains and the risk of heterosexual HIV-1 transmission. Methods: Sera from 39 infected individuals (16 transmitters and 23 non-transmitters) were tested for reactivity against synthetic peptides representing sequences of the V3 loop apex from HIV-1 strains MN, SC, WMJ2, RF and IIIB. Results: A skewed distribution in seroreactivity to RF and IIIB peptides was observed between the two groups: reactivity was more prevalent in sera from non-transmitting than from transmitting individuals. Reactivity to the MN, SC and WMJ2 peptides was very frequent and there were no differences between the two groups. Conclusion: These data suggest that antibodies reactive with a larger set of V3 apex peptides (i.e., cross-reactive antibodies) could play a role in the prevention of heterosexual transmission.

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