Correlation between tumor necrosis factor-alpha and D-dimer levels in non-small cell lung cancer patients

F. Guadagni, P. Ferroni, S. Basili, F. Facciolo, S. Carlini, M. Crecco, F. Martini, A. Spila, R. D'Alessandro, S. Aloe, V. Cerasoli, G. Del Monte, S. Mariotti, T. C. Mineo, M. Roselli

Research output: Contribution to journalArticle

Abstract

The present study was designed to investigate whether a correlation exists between IL-6, TNF-α and coagulation (Thrombin-antithrombin, TATc) or fibrinolysis (D-dimer) activation in non-small cell lung cancer (NSCLC) patients. One hundred thirty patients with NSCLC (n=65, 53 males, mean age 65±8, adenocarcinoma n=32, squamous cancer n=33) or chronic obstructive pulmonary disease (COPD) (n=65, 51 males, mean age 67±9) were studied. As control group 65 healthy donors (51 males, mean age 61±14) were also evaluated. The results obtained showed that median D-dimer levels were higher in NSCLC patients (3.0 μg/ml) compared either to COPD patients (1.1 μg/ml, P10 pg/ml) were found in 26% of NSCLC compared to 3% of COPD (P8.5 pg/ml) IL-6 levels were found in 53% of NSCLC and 21% of COPD patients, compared to 5% of control subjects (P

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalLung Cancer
Volume44
Issue number3
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Coagulation
  • D-Dimer
  • Fibrinolysis
  • Non-small-cell lung cancer
  • Thrombin-antithrombin complexes
  • Tumor necrosis factor-alpha

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Correlation between tumor necrosis factor-alpha and D-dimer levels in non-small cell lung cancer patients'. Together they form a unique fingerprint.

  • Cite this

    Guadagni, F., Ferroni, P., Basili, S., Facciolo, F., Carlini, S., Crecco, M., Martini, F., Spila, A., D'Alessandro, R., Aloe, S., Cerasoli, V., Del Monte, G., Mariotti, S., Mineo, T. C., & Roselli, M. (2004). Correlation between tumor necrosis factor-alpha and D-dimer levels in non-small cell lung cancer patients. Lung Cancer, 44(3), 303-310. https://doi.org/10.1016/j.lungcan.2003.11.009