Correlation between ultrastructural and histochemical parameters in lymphokine-activated killer (lak) cells reacting with target cells in vitro

Rosanna Nano, Sergio Barni, Enrica Capelli, Paolo Cremaschi, Caterina Catanese, Stefano Tomaselli, Caterina Nascimbene, Ennio Prosperi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ultrastructural and fluorescence data allowed us to study the most important moments of the interaction between lymphokine-activated killer (LAK) cells against target cells (Chang) in vitro. The LAK cells, maintained at low doses of recombinant interleukin-2, were able to recognize, bind and destroy the tumoral cells. Before the attack, the LAK cells were characterized by a cytoplasm with a high ribosomes content; after the identification and the interaction cell-cell, a degeneration of the tumoral cell was observed. These observations allowed us to suppose that the interaction between the two types of cells may be mediated by a receptoral membrane system without the action of lytic enzymes.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalActa Oncologica
Volume33
Issue number2
DOIs
Publication statusPublished - 1994

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Lymphokine-Activated Killer Cells
Ribosomes
Cell Communication
Interleukin-2
Cytoplasm
Fluorescence
In Vitro Techniques
Membranes
Enzymes

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Correlation between ultrastructural and histochemical parameters in lymphokine-activated killer (lak) cells reacting with target cells in vitro. / Nano, Rosanna; Barni, Sergio; Capelli, Enrica; Cremaschi, Paolo; Catanese, Caterina; Tomaselli, Stefano; Nascimbene, Caterina; Prosperi, Ennio.

In: Acta Oncologica, Vol. 33, No. 2, 1994, p. 165-169.

Research output: Contribution to journalArticle

Nano, Rosanna ; Barni, Sergio ; Capelli, Enrica ; Cremaschi, Paolo ; Catanese, Caterina ; Tomaselli, Stefano ; Nascimbene, Caterina ; Prosperi, Ennio. / Correlation between ultrastructural and histochemical parameters in lymphokine-activated killer (lak) cells reacting with target cells in vitro. In: Acta Oncologica. 1994 ; Vol. 33, No. 2. pp. 165-169.
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