Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma

Toni Valković, Frane Dobrila, Mauro Melato, Franco Sasso, Clara Rizzardi, Nives Jonjić

Research output: Contribution to journalArticlepeer-review

Abstract

Angiogenic and anti-angiogenic factors, secreted by tumor, inflammatory, and stromal cells play an important role in regulation of neovascularization. Among the most important of these is vascular endothelial growth factor (VEGF), a specific mitogen for endothelium, which increases vascular permeability and induces proteolytic enzymes necessary for vascular remodeling. Tumor-associated macrophages (TAMs) can express complex functions related to tumor biology, including growth, proliferative rate, stroma formation and dissolution, and neovascularization. The aim of this study was to define, using immunohistochemical analysis, the microvessel density (MVD), VEGF expression, and TAMs level in 97 human invasive ductal breast carcinomas not otherwise specified (NOS), investigate a possible relationship between them and then correlate their values with tumor grade, mitotic activity index (MAI), tumor size and lymph-node status. Statistical analysis showed a strong positive relationship between MVD and VEGF expression (P

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalVirchows Archiv
Volume440
Issue number6
DOIs
Publication statusPublished - 2002

Keywords

  • Angiogenesis
  • Breast carcinoma
  • Tumor-associated macrophages
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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