Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

D. Ribatti; G. Polimeno; A. Vacca; A. Marzullo; E. Crivellato; B. Nico; G. Lucarelli; F. Dammacco

doi:10.1038/sj.leu.2402586

Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

D. Ribatti, G. Polimeno, A. Vacca, A. Marzullo, E. Crivellato, B. Nico, G. Lucarelli, F. Dammacco

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

Original language	English
Pages (from-to)	1680-1684
Number of pages	5
Journal	Leukemia
Volume	16
Issue number	9
DOIs	https://doi.org/10.1038/sj.leu.2402586
Publication status	Published - Sep 2002

Keywords

Angiogenesis
Mast cells
Myelodysplastic syndrome
Tryptase
Tumor progression

ASJC Scopus subject areas

Hematology
Cancer Research

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10.1038/sj.leu.2402586

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title = "Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes",

abstract = "Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.",

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AU - Ribatti, D.

AU - Polimeno, G.

AU - Vacca, A.

AU - Marzullo, A.

AU - Crivellato, E.

AU - Nico, B.

AU - Lucarelli, G.

AU - Dammacco, F.

PY - 2002/9

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AB - Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

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KW - Mast cells

KW - Myelodysplastic syndrome

KW - Tryptase

KW - Tumor progression

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Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

Abstract

Keywords

ASJC Scopus subject areas

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