Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes

D. Ribatti, G. Polimeno, A. Vacca, A. Marzullo, E. Crivellato, B. Nico, G. Lucarelli, F. Dammacco

Research output: Contribution to journalArticle

Abstract

Bone marrow samples from 30 patients with myelodysplastic syndromes (MDS) grouped according to the International Prognostic Scoring System for MDS were investigated for counts of microvessels, total metachromatic mast cells (MC) and MC expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in patients with a poor prognosis. The observation of a high correlation between microvessel counts and both total metachromatic and tryptase-reactive MC in all samples suggests that angiogenesis in MDS increases with their progression and that MC may intervene in the angiogenic response in MDS through tryptase contained in their secretory granules.

Original languageEnglish
Pages (from-to)1680-1684
Number of pages5
JournalLeukemia
Volume16
Issue number9
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Angiogenesis
  • Mast cells
  • Myelodysplastic syndrome
  • Tryptase
  • Tumor progression

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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    Ribatti, D., Polimeno, G., Vacca, A., Marzullo, A., Crivellato, E., Nico, B., Lucarelli, G., & Dammacco, F. (2002). Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes. Leukemia, 16(9), 1680-1684. https://doi.org/10.1038/sj.leu.2402586