Correlation of cell kinetic findings with morphology of non-hodgkin’s malignant lymphomas

Rosella Silvestrini, Rita Piazza, Alberto Riccardi, Franco Rilke

Research output: Contribution to journalArticlepeer-review

Abstract

Kinetic studies were carried out on 6 benign and 37 malignant lymph nodes from patients with non-Hodgkin’s malignant lymphomas (ML). The labeling index, DNA content, and cell distribution through the cell cycle were analyzed in the ML, which were classified according to the Kiel classification. Approximately 90% of the ML studied showed a clear diploidy; the only cases of polyploidy were limited to some centroblastic-centrocy-tic ML with more than 30% malignant centroblasts and to the single centroblastic ML. The labeling indexes ranged from 0.05 to 33%. No correlation was found between the proliferative rate and the degree of ploidy, while a grading of labeling index was found in relation to the three main DNA distribution patterns observed (i.e., G, peak, S accumulation, and bimodal distribution through the cell cycle). From a kinetic point of view, the most heterogeneous groups were the lymphoplasmacytoid (subtype polymorphous) and centroblastic-centrocytic ML, where the degree of proliferation increased as the mixture of cell type (relative to the former group) and the malignant centroblastic component (relative to the latter group) increased.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalJournal of the National Cancer Institute
Volume58
Issue number3
DOIs
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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