Abstract
Kinetic studies were carried out on 6 benign and 37 malignant lymph nodes from patients with non-Hodgkin’s malignant lymphomas (ML). The labeling index, DNA content, and cell distribution through the cell cycle were analyzed in the ML, which were classified according to the Kiel classification. Approximately 90% of the ML studied showed a clear diploidy; the only cases of polyploidy were limited to some centroblastic-centrocy-tic ML with more than 30% malignant centroblasts and to the single centroblastic ML. The labeling indexes ranged from 0.05 to 33%. No correlation was found between the proliferative rate and the degree of ploidy, while a grading of labeling index was found in relation to the three main DNA distribution patterns observed (i.e., G, peak, S accumulation, and bimodal distribution through the cell cycle). From a kinetic point of view, the most heterogeneous groups were the lymphoplasmacytoid (subtype polymorphous) and centroblastic-centrocytic ML, where the degree of proliferation increased as the mixture of cell type (relative to the former group) and the malignant centroblastic component (relative to the latter group) increased.
| Original language | English |
|---|---|
| Pages (from-to) | 499-504 |
| Number of pages | 6 |
| Journal | Journal of the National Cancer Institute |
| Volume | 58 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1977 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Correlation of cell kinetic findings with morphology of non-hodgkin’s malignant lymphomas. / Silvestrini, Rosella; Piazza, Rita; Riccardi, Alberto; Rilke, Franco.
In: Journal of the National Cancer Institute, Vol. 58, No. 3, 1977, p. 499-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of cell kinetic findings with morphology of non-hodgkin’s malignant lymphomas
AU - Silvestrini, Rosella
AU - Piazza, Rita
AU - Riccardi, Alberto
AU - Rilke, Franco
PY - 1977
Y1 - 1977
N2 - Kinetic studies were carried out on 6 benign and 37 malignant lymph nodes from patients with non-Hodgkin’s malignant lymphomas (ML). The labeling index, DNA content, and cell distribution through the cell cycle were analyzed in the ML, which were classified according to the Kiel classification. Approximately 90% of the ML studied showed a clear diploidy; the only cases of polyploidy were limited to some centroblastic-centrocy-tic ML with more than 30% malignant centroblasts and to the single centroblastic ML. The labeling indexes ranged from 0.05 to 33%. No correlation was found between the proliferative rate and the degree of ploidy, while a grading of labeling index was found in relation to the three main DNA distribution patterns observed (i.e., G, peak, S accumulation, and bimodal distribution through the cell cycle). From a kinetic point of view, the most heterogeneous groups were the lymphoplasmacytoid (subtype polymorphous) and centroblastic-centrocytic ML, where the degree of proliferation increased as the mixture of cell type (relative to the former group) and the malignant centroblastic component (relative to the latter group) increased.
AB - Kinetic studies were carried out on 6 benign and 37 malignant lymph nodes from patients with non-Hodgkin’s malignant lymphomas (ML). The labeling index, DNA content, and cell distribution through the cell cycle were analyzed in the ML, which were classified according to the Kiel classification. Approximately 90% of the ML studied showed a clear diploidy; the only cases of polyploidy were limited to some centroblastic-centrocy-tic ML with more than 30% malignant centroblasts and to the single centroblastic ML. The labeling indexes ranged from 0.05 to 33%. No correlation was found between the proliferative rate and the degree of ploidy, while a grading of labeling index was found in relation to the three main DNA distribution patterns observed (i.e., G, peak, S accumulation, and bimodal distribution through the cell cycle). From a kinetic point of view, the most heterogeneous groups were the lymphoplasmacytoid (subtype polymorphous) and centroblastic-centrocytic ML, where the degree of proliferation increased as the mixture of cell type (relative to the former group) and the malignant centroblastic component (relative to the latter group) increased.
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U2 - 10.1093/jnci/58.3.499
DO - 10.1093/jnci/58.3.499
M3 - Article
VL - 58
SP - 499
EP - 504
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 3
ER -