Correlation of clinical and molecular features in spinal bulbar muscular atrophy

Pietro Fratta, Niranjanan Nirmalananthan, Luc Masset, Iwona Skorupinska, Toby Collins, Andrea Cortese, Sally Pemble, Andrea Malaspina, Elizabeth M C Fisher, Linda Greensmith, Michael G. Hanna

Research output: Contribution to journalArticle

Abstract

Objectives: To characterize the clinical and genetic features of spinal bulbar muscular atrophy (SBMA), a rare neurodegenerative disorder caused by the expansion of a CAG repeat in the first exon of the androgen receptor gene, in the United Kingdom. Methods: We created a national register for SBMA in the United Kingdom and recruited 61 patients between 2005 and 2013. In our cross-sectional study, we assessed, by direct questioning, impairment of activities of daily living (ADL) milestones, functional rating, and subjective disease impact, and performed correlations with both CAG repeat size and degree of somatic mosaicism. Ten patients were deceased, 46 patients participated in the study, and = declined. Results: Subjects had an average age at onset of 43.4 years, and weakness onset most frequently occurred in the lower limbs (87%). Impaired mobility was the most frequently reported problem by patients, followed by bulbar dysfunction. Age distribution of the impairment of ADL milestones showed remarkable overlap with a Japanese study. We have identified a significant correlation between the number of CAG repeats and both age at onset and ADL milestones. Somatic mosaicism also showed a correlation with CAG expansion size and age at onset. Conclusions: Clinical features in SBMA show a substantial overlap when comparing populations with different genetic backgrounds. This finding has major implications, because multicenter trials will be necessary to obtain sufficient power in future clinical trials. Clinical-genetic correlations are strong in SBMA and should inform any clinical research strategy in this condition.

Original languageEnglish
Pages (from-to)2077-2084
Number of pages8
JournalNeurology
Volume82
Issue number23
DOIs
Publication statusPublished - Jun 10 2014

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Atrophic Muscular Disorders
Activities of Daily Living
Age of Onset
Mosaicism
Age Distribution
Androgen Receptors
Neurodegenerative Diseases
Multicenter Studies
Lower Extremity
Exons
Cross-Sectional Studies
Clinical Trials
Onset
Research
Population
Genes
Repeats

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Fratta, P., Nirmalananthan, N., Masset, L., Skorupinska, I., Collins, T., Cortese, A., ... Hanna, M. G. (2014). Correlation of clinical and molecular features in spinal bulbar muscular atrophy. Neurology, 82(23), 2077-2084. https://doi.org/10.1212/WNL.0000000000000507

Correlation of clinical and molecular features in spinal bulbar muscular atrophy. / Fratta, Pietro; Nirmalananthan, Niranjanan; Masset, Luc; Skorupinska, Iwona; Collins, Toby; Cortese, Andrea; Pemble, Sally; Malaspina, Andrea; Fisher, Elizabeth M C; Greensmith, Linda; Hanna, Michael G.

In: Neurology, Vol. 82, No. 23, 10.06.2014, p. 2077-2084.

Research output: Contribution to journalArticle

Fratta, P, Nirmalananthan, N, Masset, L, Skorupinska, I, Collins, T, Cortese, A, Pemble, S, Malaspina, A, Fisher, EMC, Greensmith, L & Hanna, MG 2014, 'Correlation of clinical and molecular features in spinal bulbar muscular atrophy', Neurology, vol. 82, no. 23, pp. 2077-2084. https://doi.org/10.1212/WNL.0000000000000507
Fratta P, Nirmalananthan N, Masset L, Skorupinska I, Collins T, Cortese A et al. Correlation of clinical and molecular features in spinal bulbar muscular atrophy. Neurology. 2014 Jun 10;82(23):2077-2084. https://doi.org/10.1212/WNL.0000000000000507
Fratta, Pietro ; Nirmalananthan, Niranjanan ; Masset, Luc ; Skorupinska, Iwona ; Collins, Toby ; Cortese, Andrea ; Pemble, Sally ; Malaspina, Andrea ; Fisher, Elizabeth M C ; Greensmith, Linda ; Hanna, Michael G. / Correlation of clinical and molecular features in spinal bulbar muscular atrophy. In: Neurology. 2014 ; Vol. 82, No. 23. pp. 2077-2084.
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