Correlation of clinical function and muscle CT scan images in limb-girdle muscular dystrophy

M. Vlak, E. Van Der Kooi, C. Angelini

Research output: Contribution to journalArticle

Abstract

Knowledge of selective muscle-involvement is useful to the clinician. Therefore we investigated in sarcoglycanopathy and dysferlinopathy: (i) the correlation between clinical scale, MRC scale and CT findings and (ii) the muscles involved. Patients with a definite diagnosis of dysferlinopathy and sarcoglycanopathy were tested for their clinical functions and muscle strength and assigned a functional grade. Nineteen muscles were evaluated by CT. In dysferlinopathy, distal lower-limb muscles are involved, while in sarcoglycanopathy proximal muscles are more affected. In both groups, muscles with MRC 4 could be either normal or abnormal. Dysferlinopathy and sarcoglycanopathy have different and selective muscle involvement. This may affect certain types of functional activity. There is a possible relationship between CT findings and MRC grade in muscles with a low (

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number9
Publication statusPublished - 2000

Keywords

  • Clinical scale
  • CT scan
  • Limb-girdle muscular dystrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Psychiatry and Mental health
  • Dermatology

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