TY - JOUR
T1 - Correlation of computed tomography densitometry and pathological grading of emphysema with the variation of respiratory function after lobectomy for lung cancer
AU - Carretta, Angelo
AU - Ciriaco, Paola
AU - Melloni, Giulio
AU - Ballarin, Andrea
AU - Bandiera, Alessandro
AU - Sestini, Stefano
AU - Giovanardi, Michele
AU - Zannini, Piero
PY - 2010/6
Y1 - 2010/6
N2 - The presence of emphysema may lead to an underestimation of postoperative respiratory function after lobectomy when evaluated by standard functional assessment. The aim of the study was to assess the correlation between computed tomography (CT) densitometry, pathological grading of emphysema and variation of pulmonary function after lobectomy for lung cancer. Forty-one patients entered the study. Respiratory function was assessed preoperatively and after a mean period of 4.04 months following surgery. Postoperative function remained unchanged or increased after surgery in nine patients (Group A). In the remaining 32 patients (Group B) postoperative function was reduced after surgery. Preoperative forced expiratory volume in 1 s (FEV1)% was 68.5±13.1% in Group A and 91.7±21.0% in Group B. CT densitometry of the lobe to be resected was -877.8±57.6 HU in Group A and -827.5±64.4 HU in Group B. Pathological grading of emphysema of the resected lobe (range 0-10) was 4.1±2.2 in Group A and 3.1±1.2 in Group B. A significant correlation was observed (Spearman rank correlation) between the variation of FEV, and preoperative FEV, (P=0.003; r=-0.455), CT quantitative assessment (P=0.036; r=-0.430) and pathological grading (P=0.008; r=0.673). Patients with a higher degree of emphysema had a lower reduction of respiratory function after lobectomy and CT densitometry and pathological grading of emphysema correlated with the variation in respiratory function.
AB - The presence of emphysema may lead to an underestimation of postoperative respiratory function after lobectomy when evaluated by standard functional assessment. The aim of the study was to assess the correlation between computed tomography (CT) densitometry, pathological grading of emphysema and variation of pulmonary function after lobectomy for lung cancer. Forty-one patients entered the study. Respiratory function was assessed preoperatively and after a mean period of 4.04 months following surgery. Postoperative function remained unchanged or increased after surgery in nine patients (Group A). In the remaining 32 patients (Group B) postoperative function was reduced after surgery. Preoperative forced expiratory volume in 1 s (FEV1)% was 68.5±13.1% in Group A and 91.7±21.0% in Group B. CT densitometry of the lobe to be resected was -877.8±57.6 HU in Group A and -827.5±64.4 HU in Group B. Pathological grading of emphysema of the resected lobe (range 0-10) was 4.1±2.2 in Group A and 3.1±1.2 in Group B. A significant correlation was observed (Spearman rank correlation) between the variation of FEV, and preoperative FEV, (P=0.003; r=-0.455), CT quantitative assessment (P=0.036; r=-0.430) and pathological grading (P=0.008; r=0.673). Patients with a higher degree of emphysema had a lower reduction of respiratory function after lobectomy and CT densitometry and pathological grading of emphysema correlated with the variation in respiratory function.
KW - CT densitometry
KW - Emphysema
KW - Histology
KW - Lung cancer
KW - Respiratory function
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U2 - 10.1510/icvts.2009.223974
DO - 10.1510/icvts.2009.223974
M3 - Article
C2 - 20308264
AN - SCOPUS:77954549126
VL - 10
SP - 914
EP - 918
JO - Interactive Cardiovascular and Thoracic Surgery
JF - Interactive Cardiovascular and Thoracic Surgery
SN - 1569-9293
IS - 6
ER -