Correlation of dose with toxicity and tumour response to 90Y- and 177Lu-PRRT provides the basis for optimization through individualized treatment planning

Research output: Contribution to journalArticle

Abstract

Purpose: Peptide receptor radionuclide therapy (PRRT) with 90Y-labelled and 177Lu-labelled peptides is an effective strategy for the treatment of metastatic/nonresectable neuroendocrine tumours (NETs). Dosimetry provides important information useful for optimizing PRRT with individualized regimens to reduce toxicity and increase tumour responses. However, this strategy is not applied in routine clinical practice, despite the fact that several dosimetric studies have demonstrated significant dose–effect correlations for normal organ toxicity and tumour response that can better guide therapy planning. The present study reviews the key relationships and the radiobiological models available in the literature with the aim of providing evidence that optimization of PRRT is feasible through the implementation of dosimetry. Methods: The MEDLINE database was searched combining specific keywords. Original studies published in the English language reporting dose–effect outcomes in patients treated with PRRT were chosen. Results: Nine of 126 studies were selected from PubMed, and a further five were added manually, reporting on 590 patients. The studies were analysed and are discussed in terms of weak and strong elements of correlations. Conclusion: Several studies provided evidence of clinical benefit from the implementation of dosimetry in PRRT, indicating the potential contribution of this approach to reducing severe toxicity and/or reducing undertreatment that commonly occurs. Prospective trials, possibly multicentre, with larger numbers of patients undergoing quantitative dosimetry and with standardized methodologies should be carried out to definitively provide robust predictive paradigms to establish effective tailored PRRT. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
Original languageEnglish
Pages (from-to)2426-2441
Number of pages16
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume45
Issue number13
DOIs
Publication statusPublished - 2018

Keywords

  • Absorbed dose correlations
  • Dose–effect
  • Dose–toxicity
  • Dosimetry
  • Peptide receptor radionuclide therapy (PRRT)
  • creatinine
  • dotatate y 90
  • dotatoc y 90
  • lutetium 177
  • radiopharmaceutical agent
  • unclassified drug
  • yttrium 90
  • bibliographic database
  • cancer patient
  • clinical practice
  • comparative study
  • creatinine clearance
  • dose response
  • dosimetry
  • drug efficacy
  • drug potency
  • follow up
  • glomerulus filtration rate
  • human
  • national health organization
  • nephrotoxicity
  • neuroendocrine tumor
  • peptide receptor radionuclide therapy
  • practice guideline
  • radioisotope therapy
  • renal protection
  • Review
  • risk factor
  • treatment planning
  • world health organization

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