Correlation of global and gene-specific DNA methylation in maternal-infant pairs

Molly L. Kile, Andrea Baccarelli, Letizia Tarantini, Elaine Hoffman, Robert O. Wright, David C. Christiani

Research output: Contribution to journalArticle

Abstract

The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly selected from a prospective birth cohort in Bangladesh, we quantified DNA methylation by pyrosequencing seven CpG positions in the promoter region of p16, four CpG positions in the promoter region of p53, LINE-1 and Alu. Positive correlations were observed between maternal and umbilical cord blood at p16, LINE-1, and Alu but not p53. Multiple linear regression models observed a significant association between maternal and umbilical cord blood at LINE-1 and Alu (LINE-1: β = 0.63, p

Original languageEnglish
Article numbere13730
JournalPLoS One
Volume5
Issue number10
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Correlation of global and gene-specific DNA methylation in maternal-infant pairs'. Together they form a unique fingerprint.

  • Cite this

    Kile, M. L., Baccarelli, A., Tarantini, L., Hoffman, E., Wright, R. O., & Christiani, D. C. (2010). Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One, 5(10), [e13730]. https://doi.org/10.1371/journal.pone.0013730