Correlation of lesional skin corneometry values with serum E-selectin levels and disease severity in patients affected by plaque-type psoriasis: Recovery after effective therapy

M. Carducci, A. Mussi, C. Bonifati, R. Tomaselli, M. T. Onorati, E. Trento, F. Ameglio

Research output: Contribution to journalArticlepeer-review

Abstract

Ten subjects with plaque-type psoriasis (5 females, 5 males, median age 47, range 20-71 years, median psoriasis area and severity index [PASI] score=15.5, range 8.1-23.0) were observed before (week 0) and at the second and sixth week after starting treatment (PASI=10.5, range 7.8-14.6; PASI=8.5, range 1.6-11.6, respectively). At each of these times, the patients were evaluated for both lesional and unlesional skin corneometry and serum E- selectin values, previously shown to be increased in psoriatic subjects. At time 0, both the corneometry and the E-selectin values were significantly correlated with the PASI, infiltration and desquamation scores. As expected, the corneometry was statistically higher in the unlesional than in the lesional areas (p

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalJournal of Dermatology
Volume22
Issue number7
Publication statusPublished - 1995

Keywords

  • corneometry
  • PASI
  • psoriasis
  • serum E-selectin
  • treatment

ASJC Scopus subject areas

  • Dermatology

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