Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis

Sabina Cauci, Secondo Guaschino, Silvia Driussi, Davide De Santo, Paolo Lanzafame, Franco Quadrifoglio

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Mucosal immune system activation may represent a critical determinant of adverse consequences associated with bacterial vaginosis (BV), such as sexual human immunodeficiency virus transmission, upper genital tract infections, postsurgical infections, and adverse pregnancy outcomes. Concentrations of sialidase, prolidase, and anti-Gardnerella vaginalis hemolysin (Gvh) immunoglobulin A (IgA) were higher in vaginal fluids of 75 fertile women with BV, compared with concentrations in vaginal fluids of 85 healthy control subjects. Interleukin (IL)-8 levels were positively associated with anti-Gvh IgA response and inversely correlated with high levels of prolidase and sialidase in women with BV. IL-8 concentration was strongly associated with leukocyte count in both healthy and BV-positive women. The absence of leukocytes in most women with BV likely is due to lack of IL-8 induction. Parallel impairment of innate and adaptive mucosal immune factors, likely through microbial hydrolytic effects, may allow for the ascent of microorganisms to the upper genital tract and may facilitate viral infections.

Original languageEnglish
Pages (from-to)1614-1620
Number of pages7
JournalJournal of Infectious Diseases
Volume185
Issue number11
DOIs
Publication statusPublished - Jun 1 2002

Fingerprint

proline dipeptidase
Gardnerella vaginalis
Bacterial Vaginosis
Hemolysin Proteins
Neuraminidase
Interleukin-8
Immunoglobulin A
Reproductive Tract Infections
Immunologic Factors
Virus Diseases
Pregnancy Outcome
Leukocyte Count
Immune System
Healthy Volunteers
Leukocytes
HIV
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. / Cauci, Sabina; Guaschino, Secondo; Driussi, Silvia; De Santo, Davide; Lanzafame, Paolo; Quadrifoglio, Franco.

In: Journal of Infectious Diseases, Vol. 185, No. 11, 01.06.2002, p. 1614-1620.

Research output: Contribution to journalArticle

Cauci, Sabina ; Guaschino, Secondo ; Driussi, Silvia ; De Santo, Davide ; Lanzafame, Paolo ; Quadrifoglio, Franco. / Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. 11. pp. 1614-1620.
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