Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma

Giovanni Corso, Corrado Pedrazzani, Daniele Marrelli, Valeria Pascale, Enrico Pinto, Franco Roviello

Research output: Contribution to journalArticle

Abstract

Hypothesis: Microsatellite instability (MSI) correlates with clinicopathologic characteristics and long-term prognosis in patients having gastric carcinoma. Design: Analysis of prospectively collected data and biologic material. Setting: Tertiary University Hospital, Policlinico "Le Scotte," Siena, Italy. Patients: Two hundred fifty patients with gastric carcinoma. Main Outcome Measures: Five mononucleotide repeats (BAT-26, BAT-25, NR-24, NR-21, and NR-27) were analyzed in these patients. Results: An MSI phenotype was identified in 63 patients (25.2%) and correlated with specific clinicopathologic characteristics. Favorable prognosis was confirmed for patients with an MSI phenotype in univariate (P

Original languageEnglish
Pages (from-to)722-727
Number of pages6
JournalArchives of Surgery
Volume144
Issue number8
DOIs
Publication statusPublished - Aug 2009

ASJC Scopus subject areas

  • Surgery

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