Correlation of parents' longevity with carotid intima-media thickness in patients attending a Lipid Clinic

Damiano Baldassarre, Mauro Amato, Fabrizio Veglia, Linda Pustina, Samuela Castelnuovo, Silvia Sanvito, Lorenzo Gerosa, Cesare R. Sirtori, Elena Tremoli

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship between carotid intima-media thickness (IMT) and the subject's parents' longevity has been investigated. The association between parents' age at death and IMT was estimated in 593 consecutive patients attending a Lipid Clinic by survival-analysis methods. Average maximum IMT (Avg-IMT), maximum IMT (Max-IMT), clinical and laboratory variables and parental age at death, were assessed. Kaplan-Meier analyses showed significant differences in survival curves, low IMTs being associated with long-lived parents (p = 0.0003 and 0.001 by log-rank test for fathers and mothers, respectively). A Cox proportional hazards regression model showed that higher carotid IMT values were associated with father's and mother's deaths at an early age, even after adjusting for conventional cardiovascular risk factors. These data were confirmed after the stratification of patients into younger (

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalAtherosclerosis
Volume179
Issue number1
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Atherosclerosis
  • Carotid arteries
  • Intima-media thickness
  • Longevity
  • Parental age

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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