Correlation of peripapillary retinal nerve fibre layer thickness with visual acuity in paediatric patients affected by optic pathway glioma

Raffaele Parrozzani, Giacomo Miglionico, Francesca Leonardi, Serena Pulze, Eva Trevisson, Maurizio Clementi, Enrico Opocher, Viviana Licata, Elisabetta Viscardi, Elisabetta Pilotto, Luisa Frizziero, Edoardo Midena

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness, measured by spectral-domain optical coherence tomography (SD-OCT), as a surrogate of visual function in a population of paediatric patients affected by optic pathway glioma (OPG) associated with neurofibromatosis type 1 (NF1). Methods: A total of 38 paediatric patients (66 eyes) affected by MRI-proven OPG were included. Each patient underwent complete ophthalmological examination, including age-appropriate visual acuity (VA) assessment and RNFL analysis by SD-OCT. Visual acuity was classified as normal or pathologic using age-based normative data. Visual acuity was correlated to mean RNFL thickness of the whole peripapillary area and of each single analyzed sector (nasal, superior, temporal, inferior). Results: Visual acuity was normal in 43 (65%) and pathologic in 23 (35%) eyes. Mean parapapillary RNFL thickness of each analyzed sector was significantly lower in eyes with abnormal VA (p < 0.05). The best balanced cut-off value of global RNFL thickness allowing to discriminate between eyes with normal and pathologic VA was 76.25 μm (91%, 76%, 67% and 94% of sensitivity, specificity, positive and negative predicting value, respectively). Considering best balanced cut-off values of other analyzed RNFL sectors, the superior (p = 0.0029) and the inferior (p = 0.0024) sectors reached the higher sensitivity (87% and 87%, respectively) and specificity (81% and 79%, respectively). Conclusion: Retinal nerve fibre layer thickness is directly related to VA in children affected by NF1-related OPG, and should be considered as a potential surrogate marker of VA. Retinal nerve fibre layer thickness cut-off values can be used in paediatric patients to discriminate false-positive results obtained by VA measurement.

Original languageEnglish
Pages (from-to)e1004-e1009
JournalActa Ophthalmologica
Volume96
Issue number8
DOIs
Publication statusPublished - Dec 1 2018

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Optic Nerve Glioma
Nerve Fibers
Visual Acuity
Pediatrics
Neurofibromatosis 1
Optical Coherence Tomography
Nose
Biomarkers

Keywords

  • neuro ophthalmology
  • neurofibromatosis
  • optic pathway glioma
  • optical coherence tomography
  • paediatric ophthalmology
  • visual acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Correlation of peripapillary retinal nerve fibre layer thickness with visual acuity in paediatric patients affected by optic pathway glioma. / Parrozzani, Raffaele; Miglionico, Giacomo; Leonardi, Francesca; Pulze, Serena; Trevisson, Eva; Clementi, Maurizio; Opocher, Enrico; Licata, Viviana; Viscardi, Elisabetta; Pilotto, Elisabetta; Frizziero, Luisa; Midena, Edoardo.

In: Acta Ophthalmologica, Vol. 96, No. 8, 01.12.2018, p. e1004-e1009.

Research output: Contribution to journalArticle

Parrozzani, Raffaele ; Miglionico, Giacomo ; Leonardi, Francesca ; Pulze, Serena ; Trevisson, Eva ; Clementi, Maurizio ; Opocher, Enrico ; Licata, Viviana ; Viscardi, Elisabetta ; Pilotto, Elisabetta ; Frizziero, Luisa ; Midena, Edoardo. / Correlation of peripapillary retinal nerve fibre layer thickness with visual acuity in paediatric patients affected by optic pathway glioma. In: Acta Ophthalmologica. 2018 ; Vol. 96, No. 8. pp. e1004-e1009.
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abstract = "Purpose: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness, measured by spectral-domain optical coherence tomography (SD-OCT), as a surrogate of visual function in a population of paediatric patients affected by optic pathway glioma (OPG) associated with neurofibromatosis type 1 (NF1). Methods: A total of 38 paediatric patients (66 eyes) affected by MRI-proven OPG were included. Each patient underwent complete ophthalmological examination, including age-appropriate visual acuity (VA) assessment and RNFL analysis by SD-OCT. Visual acuity was classified as normal or pathologic using age-based normative data. Visual acuity was correlated to mean RNFL thickness of the whole peripapillary area and of each single analyzed sector (nasal, superior, temporal, inferior). Results: Visual acuity was normal in 43 (65{\%}) and pathologic in 23 (35{\%}) eyes. Mean parapapillary RNFL thickness of each analyzed sector was significantly lower in eyes with abnormal VA (p < 0.05). The best balanced cut-off value of global RNFL thickness allowing to discriminate between eyes with normal and pathologic VA was 76.25 μm (91{\%}, 76{\%}, 67{\%} and 94{\%} of sensitivity, specificity, positive and negative predicting value, respectively). Considering best balanced cut-off values of other analyzed RNFL sectors, the superior (p = 0.0029) and the inferior (p = 0.0024) sectors reached the higher sensitivity (87{\%} and 87{\%}, respectively) and specificity (81{\%} and 79{\%}, respectively). Conclusion: Retinal nerve fibre layer thickness is directly related to VA in children affected by NF1-related OPG, and should be considered as a potential surrogate marker of VA. Retinal nerve fibre layer thickness cut-off values can be used in paediatric patients to discriminate false-positive results obtained by VA measurement.",
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AU - Parrozzani, Raffaele

AU - Miglionico, Giacomo

AU - Leonardi, Francesca

AU - Pulze, Serena

AU - Trevisson, Eva

AU - Clementi, Maurizio

AU - Opocher, Enrico

AU - Licata, Viviana

AU - Viscardi, Elisabetta

AU - Pilotto, Elisabetta

AU - Frizziero, Luisa

AU - Midena, Edoardo

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N2 - Purpose: To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness, measured by spectral-domain optical coherence tomography (SD-OCT), as a surrogate of visual function in a population of paediatric patients affected by optic pathway glioma (OPG) associated with neurofibromatosis type 1 (NF1). Methods: A total of 38 paediatric patients (66 eyes) affected by MRI-proven OPG were included. Each patient underwent complete ophthalmological examination, including age-appropriate visual acuity (VA) assessment and RNFL analysis by SD-OCT. Visual acuity was classified as normal or pathologic using age-based normative data. Visual acuity was correlated to mean RNFL thickness of the whole peripapillary area and of each single analyzed sector (nasal, superior, temporal, inferior). Results: Visual acuity was normal in 43 (65%) and pathologic in 23 (35%) eyes. Mean parapapillary RNFL thickness of each analyzed sector was significantly lower in eyes with abnormal VA (p < 0.05). The best balanced cut-off value of global RNFL thickness allowing to discriminate between eyes with normal and pathologic VA was 76.25 μm (91%, 76%, 67% and 94% of sensitivity, specificity, positive and negative predicting value, respectively). Considering best balanced cut-off values of other analyzed RNFL sectors, the superior (p = 0.0029) and the inferior (p = 0.0024) sectors reached the higher sensitivity (87% and 87%, respectively) and specificity (81% and 79%, respectively). Conclusion: Retinal nerve fibre layer thickness is directly related to VA in children affected by NF1-related OPG, and should be considered as a potential surrogate marker of VA. Retinal nerve fibre layer thickness cut-off values can be used in paediatric patients to discriminate false-positive results obtained by VA measurement.

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KW - neurofibromatosis

KW - optic pathway glioma

KW - optical coherence tomography

KW - paediatric ophthalmology

KW - visual acuity

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