Correlation of SD-OCT findings and visual function in patients with retinitis pigmentosa

Maurizio Battaglia Parodi, Carlo La Spina, Giacinto Triolo, Fulvio Riccieri, Luisa Pierro, Marco Gagliardi, Francesco Bandello

Research output: Contribution to journalArticle

Abstract

Purpose: To describe the morphological macular changes detected by spectral domain optical coherence tomography (SD-OCT) in eyes with retinitis pigmentosa (RP) and to analyze their correlation with the visual function. Methods: Twenty-two patients (44 eyes) patients affected by RP were recruited. The following structures were evaluated on SD-OCT: outer plexiform layer (OPL), outer nuclear layer (ONL), external limiting membrane (ELM), photoreceptor inner/outer segment (IS/OS) junction, photoreceptor outer segment/retinal pigmented epithelium (OS/RPE) junction, inner limiting membrane thickening (ILMT), ganglion cell complex (GCC), and cystoid macular edema (CME). The relation between each SD-OCT finding and BCVA was evaluated at uni- and multivariate analysis. Results: Mean age and mean best-corrected visual acuity (BCVA) were 51 ± 17.5 years and 0.4 ± 0.5 LogMAR, respectively. Univariate linear regression model revealed a correlation between BCVA and the absence of ELM, IS/OS, ONL, and OS/RPE layers (R2 values were, respectively, 0.51, 0.57, 0.48, and 0.68, with p values all
Original languageEnglish
Pages (from-to)1275 - 1279
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume254
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • Retinitis pigmentosa
  • Spectral domain OCT
  • Visual acuity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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