Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis

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Abstract

We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean ± SD 92.1 ± 75.1 hybridoma growth factor units/ml; P <0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P <0.001) and with platelet counts (P <0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.

Original languageEnglish
Pages (from-to)1158-1163
Number of pages6
JournalArthritis and Rheumatism
Volume34
Issue number9
Publication statusPublished - Sep 1991

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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