Correlations between physico-chemical parameters and biological activities of heparin and heparin-like substances, of current interest because of the increasing use of these polysaccharides in therapy, were investigated with respect to anticomplement, anticoagulant, and platelet-aggregating activities. While the anticoagulant and platelet-aggregating activities appear to be related to both the sulfate content and the degree of carboxylation of the polysaccharide, its anticomplement activity depends primarly on the sulfate content. Reduction of the carboxyl groups of heparin brings about a substantial loss of anticoagulant activity, but no significant decrease of the anticomplement activity.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine