Correlation of sulfate content and degree of carboxylation of heparin and related glycosaminoglycans with anticomplement activity. Relationships to the anticoagulant and platelet-aggregating activities

E. Cofrancsco, F. Radaelli, E. Pogliania, N. Amici, G. G. Torri, B. Casu

Research output: Contribution to journalArticlepeer-review

Abstract

Correlations between physico-chemical parameters and biological activities of heparin and heparin-like substances, of current interest because of the increasing use of these polysaccharides in therapy, were investigated with respect to anticomplement, anticoagulant, and platelet-aggregating activities. While the anticoagulant and platelet-aggregating activities appear to be related to both the sulfate content and the degree of carboxylation of the polysaccharide, its anticomplement activity depends primarly on the sulfate content. Reduction of the carboxyl groups of heparin brings about a substantial loss of anticoagulant activity, but no significant decrease of the anticomplement activity.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalThrombosis Research
Volume14
Issue number1
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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