Abstract
OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..
| Original language | English |
|---|---|
| Pages (from-to) | 305-312 |
| Number of pages | 8 |
| Journal | European Journal of Gastroenterology and Hepatology |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 6 2015 |
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Keywords
- controlled attenuation parameter
- correlation studies
- dual-energy X-ray absorptiometry
- liver steatosis
- magnetic resonance
- obesity
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
- Medicine(all)
Cite this
Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals : A pilot study. / Ferraioli, Giovanna; Tinelli, Carmine; Lissandrin, Raffaella; Zicchetti, Mabel; Faliva, Milena; Perna, Simone; Perani, Guido; Alessandrino, Francesco; Calliada, Fabrizio; Rondanelli, Mariangela; Filice, Carlo.
In: European Journal of Gastroenterology and Hepatology, Vol. 27, No. 3, 06.03.2015, p. 305-312.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals
T2 - A pilot study
AU - Ferraioli, Giovanna
AU - Tinelli, Carmine
AU - Lissandrin, Raffaella
AU - Zicchetti, Mabel
AU - Faliva, Milena
AU - Perna, Simone
AU - Perani, Guido
AU - Alessandrino, Francesco
AU - Calliada, Fabrizio
AU - Rondanelli, Mariangela
AU - Filice, Carlo
PY - 2015/3/6
Y1 - 2015/3/6
N2 - OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..
AB - OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..
KW - controlled attenuation parameter
KW - correlation studies
KW - dual-energy X-ray absorptiometry
KW - liver steatosis
KW - magnetic resonance
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=84922309538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922309538&partnerID=8YFLogxK
U2 - 10.1097/MEG.0000000000000287
DO - 10.1097/MEG.0000000000000287
M3 - Article
C2 - 25629575
AN - SCOPUS:84922309538
VL - 27
SP - 305
EP - 312
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 3
ER -