Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals: A pilot study

Giovanna Ferraioli, Carmine Tinelli, Raffaella Lissandrin, Mabel Zicchetti, Milena Faliva, Simone Perna, Guido Perani, Francesco Alessandrino, Fabrizio Calliada, Mariangela Rondanelli, Carlo Filice

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 6 2015

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Fatty Liver
Photon Absorptiometry
Fats
Abdominal Obesity
Liver
Waist Circumference

Keywords

  • controlled attenuation parameter
  • correlation studies
  • dual-energy X-ray absorptiometry
  • liver steatosis
  • magnetic resonance
  • obesity

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals : A pilot study. / Ferraioli, Giovanna; Tinelli, Carmine; Lissandrin, Raffaella; Zicchetti, Mabel; Faliva, Milena; Perna, Simone; Perani, Guido; Alessandrino, Francesco; Calliada, Fabrizio; Rondanelli, Mariangela; Filice, Carlo.

In: European Journal of Gastroenterology and Hepatology, Vol. 27, No. 3, 06.03.2015, p. 305-312.

Research output: Contribution to journalArticle

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T1 - Correlation of the controlled attenuation parameter with indices of liver steatosis in overweight or obese individuals

T2 - A pilot study

AU - Ferraioli, Giovanna

AU - Tinelli, Carmine

AU - Lissandrin, Raffaella

AU - Zicchetti, Mabel

AU - Faliva, Milena

AU - Perna, Simone

AU - Perani, Guido

AU - Alessandrino, Francesco

AU - Calliada, Fabrizio

AU - Rondanelli, Mariangela

AU - Filice, Carlo

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N2 - OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..

AB - OBJECTIVE: The aim of this study was to assess the clinical relevance of the controlled attenuation parameter (CAP) by analyzing the correlations between CAP and indirect indices of liver steatosis in obese or overweight individuals. METHODS: Consecutive participants were prospectively enrolled. BMI, waist circumference, hepatic steatosis index, fatty liver index, percent fat mass and regional fat masses as assessed by dual-energy X-ray absorptiometry (DXA), fat signal fraction as assessed by MRI, and CAP were obtained. Pearson's r coefficient was used to test the correlation between two study variables. RESULTS: A total of 88 individuals were studied. They included 31 men [age, 50.4 years (12.9 years); BMI, 30.7kg/m (4.8kg/m)] and 57 women [age, 49.0 years (12.6 years); BMI, 31.4kg/m (5.6kg/m)]. DXA, anthropometric parameters, and fatty liver index were moderately correlated with CAP in men. In women, there was a moderate correlation of CAP with the hepatic steatosis index and anthropometric parameters and only a slight or fair correlation of CAP with DXA parameters. CAP and fat signal fraction showed a good correlation (r=0.65 in men, P=0.002; r=0.68 in women, P=0.0009). CONCLUSION: Measurement of CAP is a reliable method for noninvasive assessment of liver steatosis, showing a correlation with other indirect markers of central obesity and a good correlation with MRI results..

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