Correlation of tumor location to clinical outcomes in colorectal cancer: A Single-institution Retrospective Analysis

Carlo Signorelli, Mario Giovanni Chilelli, Isabella Sperduti, Silvana Giacinti, Pietro Maria Amodio, Raffaele Macarone Palmieri, Teresa Valentina Ranalli, Vito Vincenzo Gomes, Maria Elena Rosetto, Fabrizio Nelli, Enzo Maria Ruggeri

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Recent data highlighted that location of metastatic colorectal cancer (mCRC) may have a prognostic impact and also a predictive value of the outcomes of first-line therapy. Materials and Methods: The records of mCRC patients who underwent first-line therapy from 2011 to April 2018 at our Institute were retrospectively reviewed. Progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) according to the primary tumor location were investigated. Results: Overall, 130 patients were eligible. Two-year OS was 82.9% in left-sided colon cancers (LCC) and 67.5% in right-sided (RCC) (p=0.32). One-year mPFS was statistically longer in LCC (46.8% vs. 24.2%, p=0.0005). mPFS was longer in LCC treated with anti-VEGF vs. anti-EGFR (p=0.06). ORR was 51.1% in LCC, 25% in RCC (p=0.008). Overall, 11 complete responses all in LCC were observed (p=0.03). Conclusion: Tumor location has a prognostic impact and might influence the outcomes of mCRC patients.

Original languageEnglish
Pages (from-to)4917-4924
Number of pages8
JournalAnticancer Research
Volume39
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • First-line therapy
  • Metastatic colorectal cancer
  • Tumor location

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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