Correlations between changes in disability and T2-weighted brain mri activity in multiple sclerosis

A follow-up study

M. Filippi, D. W. Paty, L. Kappos, F. Barkhof, D. Compston, A. J. Thompson, G. J. Zhao, C. M. Wiles, W. I. McDonald, D. H. Miller

Research output: Contribution to journalArticle

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Abstract

We obtained two conventional unenhanced T2-weighted brain MRI scans, separated by an interval of 24 to 36 months, in 281 patients with multiple sclerosis (MS). At the time of each scan, clinical disability was rated using the Kurtzke Expanded Disability Status Scale (EDSS). Changes in disability between the two examinations correlated weakly but significantly with the number of new (Spearman’s rank correlation coefficient = 0.13; p = 0.02) and enlarging (Spearman’s rank correlation coefficient = 0.18; p = 0.002) MRI lesions. This result suggests that brain T2-weighted MRI is a useful supplementary marker of disease activity in definitive (phase III) clinical treatment trials in MS.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalNeurology
Volume45
Issue number2
Publication statusPublished - 1995

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Nonparametric Statistics
Multiple Sclerosis
Phase III Clinical Trials
Brain
Magnetic Resonance Imaging
Therapeutics
Correlation Coefficient

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Filippi, M., Paty, D. W., Kappos, L., Barkhof, F., Compston, D., Thompson, A. J., ... Miller, D. H. (1995). Correlations between changes in disability and T2-weighted brain mri activity in multiple sclerosis: A follow-up study. Neurology, 45(2), 255-260.

Correlations between changes in disability and T2-weighted brain mri activity in multiple sclerosis : A follow-up study. / Filippi, M.; Paty, D. W.; Kappos, L.; Barkhof, F.; Compston, D.; Thompson, A. J.; Zhao, G. J.; Wiles, C. M.; McDonald, W. I.; Miller, D. H.

In: Neurology, Vol. 45, No. 2, 1995, p. 255-260.

Research output: Contribution to journalArticle

Filippi, M, Paty, DW, Kappos, L, Barkhof, F, Compston, D, Thompson, AJ, Zhao, GJ, Wiles, CM, McDonald, WI & Miller, DH 1995, 'Correlations between changes in disability and T2-weighted brain mri activity in multiple sclerosis: A follow-up study', Neurology, vol. 45, no. 2, pp. 255-260.
Filippi, M. ; Paty, D. W. ; Kappos, L. ; Barkhof, F. ; Compston, D. ; Thompson, A. J. ; Zhao, G. J. ; Wiles, C. M. ; McDonald, W. I. ; Miller, D. H. / Correlations between changes in disability and T2-weighted brain mri activity in multiple sclerosis : A follow-up study. In: Neurology. 1995 ; Vol. 45, No. 2. pp. 255-260.
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