TY - JOUR
T1 - Correlations between NT-proBNP, outcome and haemodynamics in patients with septic shock
AU - Guaricci, Andrea Igoren
AU - Santoro, Francesco
AU - Paoletti Perini, Alessandro
AU - Ioffredo, Luciano
AU - Trivedi, Chintan
AU - Pontone, Gianluca
AU - Di Biase, Matteo
AU - Brunetti, Natale Daniele
PY - 2015
Y1 - 2015
N2 - Aim The aim of this study was to determine the role of NT-proBNP in predicting the outcome of septic patients and to evaluate possible correlations between NT-ProBNP and haemodynamics in sepsis. Methods Forty consecutive patients with severe sepsis were prospectively evaluated. Patients were treated with the gold standard therapy for sepsis. NT-BNP levels, endotoxin activity (EA), SOFA score and SAPS II score, cardiac index (CI), mean arterial pressure (MAP) and pulmonary arterial pressure (PAP) were evaluated at admission and after 72 hours. Survival was evaluated at 28 days after admission. Results At 4-week follow-up, 22 patients had died (55%). Survival was not associated with age, gender, baseline EA and treatment, while it was associated with NT-proBNP levels at admission and after 72 hours. NT-proBNP > 1,000 pg/ml at 72 hours was a robust independent predictor of survival. The area under the curve (AUC) of NT-proBNP at admission was 0.73 and 0.99 after 72 hours. At 72 hours, AUC for SOFA score was 0.94, for SAPS II score 1, for EA 0.73. Levels of NT-proBNP > 1,000 pg/ml at 72 hours were associated with an adverse outcome (sensitivity 95.5%, specifi city 94.4%). NT-proBNP at 72 hours correlated with CI, MAP and PAP (P <0.01, <0.01,<0.05 respectively). Conclusions Increased NT-proBNP levels at 72 hours could predict mortality at 28 days in patients with septic shock and are correlated with haemodynamics.
AB - Aim The aim of this study was to determine the role of NT-proBNP in predicting the outcome of septic patients and to evaluate possible correlations between NT-ProBNP and haemodynamics in sepsis. Methods Forty consecutive patients with severe sepsis were prospectively evaluated. Patients were treated with the gold standard therapy for sepsis. NT-BNP levels, endotoxin activity (EA), SOFA score and SAPS II score, cardiac index (CI), mean arterial pressure (MAP) and pulmonary arterial pressure (PAP) were evaluated at admission and after 72 hours. Survival was evaluated at 28 days after admission. Results At 4-week follow-up, 22 patients had died (55%). Survival was not associated with age, gender, baseline EA and treatment, while it was associated with NT-proBNP levels at admission and after 72 hours. NT-proBNP > 1,000 pg/ml at 72 hours was a robust independent predictor of survival. The area under the curve (AUC) of NT-proBNP at admission was 0.73 and 0.99 after 72 hours. At 72 hours, AUC for SOFA score was 0.94, for SAPS II score 1, for EA 0.73. Levels of NT-proBNP > 1,000 pg/ml at 72 hours were associated with an adverse outcome (sensitivity 95.5%, specifi city 94.4%). NT-proBNP at 72 hours correlated with CI, MAP and PAP (P <0.01, <0.01,<0.05 respectively). Conclusions Increased NT-proBNP levels at 72 hours could predict mortality at 28 days in patients with septic shock and are correlated with haemodynamics.
KW - Haemodynamics
KW - Natriuretic peptides
KW - NT-proBNP
KW - Polymyxin B
KW - Prognosis
KW - Septic shock
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U2 - 10.2143/AC.70.5.3110515
DO - 10.2143/AC.70.5.3110515
M3 - Article
C2 - 26567814
AN - SCOPUS:84944453053
VL - 70
SP - 545
EP - 552
JO - Acta Cardiologica
JF - Acta Cardiologica
SN - 0001-5385
IS - 5
ER -