Correlative light and scanning X-ray scattering microscopy of healthy and pathologic human bone sections

C. Giannini, D. Siliqi, O. Bunk, A. Beraudi, M. Ladisa, D. Altamura, S. Stea, F. Baruffaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Scanning small and wide angle X-ray scattering (scanning SWAXS) experiments were performed on healthy and pathologic human bone sections. Via crystallographic tools the data were transformed into quantitative images and as such compared with circularly polarized light (CPL) microscopy images. SWAXS and CPL images allowed extracting information of the mineral nanocrystalline phase embedded, with and without preferred orientation, in the collagen fibrils, mapping local changes at sub-osteon resolution. This favorable combination has been applied for the first time to biopsies of dwarfism syndrome and Paget's disease to shed light onto the cortical structure of natural bone in healthy and pathologic sections.

Original languageEnglish
Article number435
JournalScientific Reports
Volume2
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • General

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