Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy

Secondary analysis of data from the CI-PeriNomS study

Kathleen A. Griffith, Susan G. Dorsey, Cynthia L. Renn, Shijun Zhu, Mary E. Johantgen, David R. Cornblath, Andreas A. Argyriou, Guido Cavaletti, Ingemar S J Merkies, Paola Alberti, Tjeerd J. Postma, Emanuela Rossi, Barbara Frigeni, Jordi Bruna, Roser Velasco, Haralabos P. Kalofonos, Dimitri Psimaras, Damien Ricard, Andrea Pace, Edvina Galie & 49 others Chiara Briani, Chiara Dalla Torre, Catharina G. Faber, Roy I. Lalisang, Willem Boogerd, Dieta Brandsma, Susanne Koeppen, Joerg Hense, Dawn J. Storey, Simon Kerrigan, Angelo Schenone, Sabrina Fabbri, Maria Grazia Valsecchi, S. Galimberti, M. Lucchetta, M. Campagnolo, E. K. Vanhoutte, M. Bakkers, B. Brouwer, R. Grant, L. Reni, B. Piras, F. Lanzani, L. Mattavelli, M. L. Piatti, P. Binda, P. Bidoli, M. Cazzaniga, D. Cortinovis, A. Pessino, L. Padua, G. Granata, M. Leandri, I. Ghignotti, R. Plasmati, F. Pastorelli, J. J. Heimans, M. Eurelings, R. J. Meijer, W. Grisold, E. Lindeck, A. Mazzeo, A. Toscano, M. Russo, C. Tomasello, G. Altavill, M. Penas Prado, C. Dominguez Gonzalez, J. Brell

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from the CIPN Outcomes Standardization (CI-PeriNomS) study for associations between clinical examinations and neurophysiological abnormalities. Logistic regression estimated the strength of associations of vibration, pin, and monofilament examinations with lower limb sensory and motor amplitudes. Examinations were classified as normal (0), moderately abnormal (1), or severely abnormal (2). Among 218 participants, those with class 1 upper extremity (UE) and classes 1 or 2 lower extremity (LE) monofilament abnormality were 2.79 (95% confidence interval [CI]: 1.28-6.07), 3.49 (95%CI: 1.61-7.55), and 4.42 (95%CI: 1.35-14.46) times more likely to have abnormal sural nerve amplitudes, respectively, compared to individuals with normal examinations. Likewise, those with class 2 UE and classes 1 or 2 LE vibration abnormality were 8.65 (95%CI: 1.81-41.42), 2.54 (95%CI: 1.19-5.41), and 7.47 (95%CI: 2.49-22.40) times more likely to have abnormal sural nerve amplitudes, respectively, compared to participants with normal examinations. Abnormalities in vibration and monofilament examinations are associated with abnormal sural nerve amplitudes and are useful in identifying CIPN.

Original languageEnglish
Pages (from-to)127-135
Number of pages9
JournalJournal of the Peripheral Nervous System
Volume19
Issue number2
DOIs
Publication statusPublished - Jun 1 2014

Fingerprint

Peripheral Nervous System Diseases
Confidence Intervals
Drug Therapy
Sural Nerve
Vibration
Lower Extremity
Upper Extremity
Logistic Models

Keywords

  • Assessment
  • Chemotherapy
  • Neurophysiology
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Medicine(all)

Cite this

Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy : Secondary analysis of data from the CI-PeriNomS study. / Griffith, Kathleen A.; Dorsey, Susan G.; Renn, Cynthia L.; Zhu, Shijun; Johantgen, Mary E.; Cornblath, David R.; Argyriou, Andreas A.; Cavaletti, Guido; Merkies, Ingemar S J; Alberti, Paola; Postma, Tjeerd J.; Rossi, Emanuela; Frigeni, Barbara; Bruna, Jordi; Velasco, Roser; Kalofonos, Haralabos P.; Psimaras, Dimitri; Ricard, Damien; Pace, Andrea; Galie, Edvina; Briani, Chiara; Dalla Torre, Chiara; Faber, Catharina G.; Lalisang, Roy I.; Boogerd, Willem; Brandsma, Dieta; Koeppen, Susanne; Hense, Joerg; Storey, Dawn J.; Kerrigan, Simon; Schenone, Angelo; Fabbri, Sabrina; Valsecchi, Maria Grazia; Galimberti, S.; Lucchetta, M.; Campagnolo, M.; Vanhoutte, E. K.; Bakkers, M.; Brouwer, B.; Grant, R.; Reni, L.; Piras, B.; Lanzani, F.; Mattavelli, L.; Piatti, M. L.; Binda, P.; Bidoli, P.; Cazzaniga, M.; Cortinovis, D.; Pessino, A.; Padua, L.; Granata, G.; Leandri, M.; Ghignotti, I.; Plasmati, R.; Pastorelli, F.; Heimans, J. J.; Eurelings, M.; Meijer, R. J.; Grisold, W.; Lindeck, E.; Mazzeo, A.; Toscano, A.; Russo, M.; Tomasello, C.; Altavill, G.; Penas Prado, M.; Dominguez Gonzalez, C.; Brell, J.

In: Journal of the Peripheral Nervous System, Vol. 19, No. 2, 01.06.2014, p. 127-135.

Research output: Contribution to journalArticle

Griffith, KA, Dorsey, SG, Renn, CL, Zhu, S, Johantgen, ME, Cornblath, DR, Argyriou, AA, Cavaletti, G, Merkies, ISJ, Alberti, P, Postma, TJ, Rossi, E, Frigeni, B, Bruna, J, Velasco, R, Kalofonos, HP, Psimaras, D, Ricard, D, Pace, A, Galie, E, Briani, C, Dalla Torre, C, Faber, CG, Lalisang, RI, Boogerd, W, Brandsma, D, Koeppen, S, Hense, J, Storey, DJ, Kerrigan, S, Schenone, A, Fabbri, S, Valsecchi, MG, Galimberti, S, Lucchetta, M, Campagnolo, M, Vanhoutte, EK, Bakkers, M, Brouwer, B, Grant, R, Reni, L, Piras, B, Lanzani, F, Mattavelli, L, Piatti, ML, Binda, P, Bidoli, P, Cazzaniga, M, Cortinovis, D, Pessino, A, Padua, L, Granata, G, Leandri, M, Ghignotti, I, Plasmati, R, Pastorelli, F, Heimans, JJ, Eurelings, M, Meijer, RJ, Grisold, W, Lindeck, E, Mazzeo, A, Toscano, A, Russo, M, Tomasello, C, Altavill, G, Penas Prado, M, Dominguez Gonzalez, C & Brell, J 2014, 'Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy: Secondary analysis of data from the CI-PeriNomS study', Journal of the Peripheral Nervous System, vol. 19, no. 2, pp. 127-135. https://doi.org/10.1111/jns5.12064
Griffith, Kathleen A. ; Dorsey, Susan G. ; Renn, Cynthia L. ; Zhu, Shijun ; Johantgen, Mary E. ; Cornblath, David R. ; Argyriou, Andreas A. ; Cavaletti, Guido ; Merkies, Ingemar S J ; Alberti, Paola ; Postma, Tjeerd J. ; Rossi, Emanuela ; Frigeni, Barbara ; Bruna, Jordi ; Velasco, Roser ; Kalofonos, Haralabos P. ; Psimaras, Dimitri ; Ricard, Damien ; Pace, Andrea ; Galie, Edvina ; Briani, Chiara ; Dalla Torre, Chiara ; Faber, Catharina G. ; Lalisang, Roy I. ; Boogerd, Willem ; Brandsma, Dieta ; Koeppen, Susanne ; Hense, Joerg ; Storey, Dawn J. ; Kerrigan, Simon ; Schenone, Angelo ; Fabbri, Sabrina ; Valsecchi, Maria Grazia ; Galimberti, S. ; Lucchetta, M. ; Campagnolo, M. ; Vanhoutte, E. K. ; Bakkers, M. ; Brouwer, B. ; Grant, R. ; Reni, L. ; Piras, B. ; Lanzani, F. ; Mattavelli, L. ; Piatti, M. L. ; Binda, P. ; Bidoli, P. ; Cazzaniga, M. ; Cortinovis, D. ; Pessino, A. ; Padua, L. ; Granata, G. ; Leandri, M. ; Ghignotti, I. ; Plasmati, R. ; Pastorelli, F. ; Heimans, J. J. ; Eurelings, M. ; Meijer, R. J. ; Grisold, W. ; Lindeck, E. ; Mazzeo, A. ; Toscano, A. ; Russo, M. ; Tomasello, C. ; Altavill, G. ; Penas Prado, M. ; Dominguez Gonzalez, C. ; Brell, J. / Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy : Secondary analysis of data from the CI-PeriNomS study. In: Journal of the Peripheral Nervous System. 2014 ; Vol. 19, No. 2. pp. 127-135.
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T1 - Correspondence between neurophysiological and clinical measurements of chemotherapy-induced peripheral neuropathy

T2 - Secondary analysis of data from the CI-PeriNomS study

AU - Griffith, Kathleen A.

AU - Dorsey, Susan G.

AU - Renn, Cynthia L.

AU - Zhu, Shijun

AU - Johantgen, Mary E.

AU - Cornblath, David R.

AU - Argyriou, Andreas A.

AU - Cavaletti, Guido

AU - Merkies, Ingemar S J

AU - Alberti, Paola

AU - Postma, Tjeerd J.

AU - Rossi, Emanuela

AU - Frigeni, Barbara

AU - Bruna, Jordi

AU - Velasco, Roser

AU - Kalofonos, Haralabos P.

AU - Psimaras, Dimitri

AU - Ricard, Damien

AU - Pace, Andrea

AU - Galie, Edvina

AU - Briani, Chiara

AU - Dalla Torre, Chiara

AU - Faber, Catharina G.

AU - Lalisang, Roy I.

AU - Boogerd, Willem

AU - Brandsma, Dieta

AU - Koeppen, Susanne

AU - Hense, Joerg

AU - Storey, Dawn J.

AU - Kerrigan, Simon

AU - Schenone, Angelo

AU - Fabbri, Sabrina

AU - Valsecchi, Maria Grazia

AU - Galimberti, S.

AU - Lucchetta, M.

AU - Campagnolo, M.

AU - Vanhoutte, E. K.

AU - Bakkers, M.

AU - Brouwer, B.

AU - Grant, R.

AU - Reni, L.

AU - Piras, B.

AU - Lanzani, F.

AU - Mattavelli, L.

AU - Piatti, M. L.

AU - Binda, P.

AU - Bidoli, P.

AU - Cazzaniga, M.

AU - Cortinovis, D.

AU - Pessino, A.

AU - Padua, L.

AU - Granata, G.

AU - Leandri, M.

AU - Ghignotti, I.

AU - Plasmati, R.

AU - Pastorelli, F.

AU - Heimans, J. J.

AU - Eurelings, M.

AU - Meijer, R. J.

AU - Grisold, W.

AU - Lindeck, E.

AU - Mazzeo, A.

AU - Toscano, A.

AU - Russo, M.

AU - Tomasello, C.

AU - Altavill, G.

AU - Penas Prado, M.

AU - Dominguez Gonzalez, C.

AU - Brell, J.

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AB - Chemotherapy-induced peripheral neuropathy (CIPN) lacks standardized clinical measurement. The objective of the current secondary analysis was to examine data from the CIPN Outcomes Standardization (CI-PeriNomS) study for associations between clinical examinations and neurophysiological abnormalities. Logistic regression estimated the strength of associations of vibration, pin, and monofilament examinations with lower limb sensory and motor amplitudes. Examinations were classified as normal (0), moderately abnormal (1), or severely abnormal (2). Among 218 participants, those with class 1 upper extremity (UE) and classes 1 or 2 lower extremity (LE) monofilament abnormality were 2.79 (95% confidence interval [CI]: 1.28-6.07), 3.49 (95%CI: 1.61-7.55), and 4.42 (95%CI: 1.35-14.46) times more likely to have abnormal sural nerve amplitudes, respectively, compared to individuals with normal examinations. Likewise, those with class 2 UE and classes 1 or 2 LE vibration abnormality were 8.65 (95%CI: 1.81-41.42), 2.54 (95%CI: 1.19-5.41), and 7.47 (95%CI: 2.49-22.40) times more likely to have abnormal sural nerve amplitudes, respectively, compared to participants with normal examinations. Abnormalities in vibration and monofilament examinations are associated with abnormal sural nerve amplitudes and are useful in identifying CIPN.

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KW - Neurophysiology

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