Cortical activation to voluntary movement in amyotrophic lateral sclerosis is related to corticospinal damage: Electrophysiological evidence

N. Riva, A. Falini, A. Inuggi, J. J. Gonzalez-Rosa, S. Amadio, F. Cerri, R. Fazio, U. Del Carro, M. Comola, G. Comi, L. Leocani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: The time course of mu and beta sensorimotor rhythms, with event-related desynchronisation (ERD) to preparation and execution of voluntary movement followed by synchronisation (ERS) after movement, is considered to indicate cortical activation and idling, respectively. We investigated ERD and ERS in amyotrophic lateral sclerosis (ALS) patients and the relationship with anatomical and neurophysiological measures of corticospinal tract damage. Methods: Pre-movement mu and beta ERD, and post-movement beta ERS were analysed in 16 ALS patients and 15 healthy controls performing self-paced brisk right thumb extensions. Apparent diffusion coefficient (ADC) of corticospinal tract was measured with magnetic resonance imaging (MRI). Motor-evoked potentials (MEPs) to the right abductor pollicis brevis were obtained using transcranial magnetic stimulation (TMS). Results: Movement-related electromyographic activity was similar in the two groups. Post-movement ERS was significantly reduced in ALS group and negatively correlated with the amount of corticospinal damage as from MRI and TMS measures. ERD did not significantly differ between groups. Conclusions: Alterations of cortical activity in ALS patients were limited to the post-movement phase, as indicated by reduced ERS, and could be linked to reduced cortical inhibition rather than to generalised hyperexcitability. Significance: The correlation between ERS and corticospinal damage severity might be interpreted as a functional compensation or dysfunction of inhibitory systems paralleling corticospinal damage.

Original languageEnglish
Pages (from-to)1586-1592
Number of pages7
JournalClinical Neurophysiology
Volume123
Issue number8
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Amyotrophic Lateral Sclerosis
Pyramidal Tracts
Transcranial Magnetic Stimulation
Beta Rhythm
Magnetic Resonance Imaging
Motor Evoked Potentials
Thumb

Keywords

  • Amyotrophic lateral sclerosis
  • Cortico-spinal tract
  • DWI
  • EEG
  • Motor neuron disease
  • Neurophysiology
  • TMS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

@article{9f7406159c0a48a69fc2b232592a378f,
title = "Cortical activation to voluntary movement in amyotrophic lateral sclerosis is related to corticospinal damage: Electrophysiological evidence",
abstract = "Objectives: The time course of mu and beta sensorimotor rhythms, with event-related desynchronisation (ERD) to preparation and execution of voluntary movement followed by synchronisation (ERS) after movement, is considered to indicate cortical activation and idling, respectively. We investigated ERD and ERS in amyotrophic lateral sclerosis (ALS) patients and the relationship with anatomical and neurophysiological measures of corticospinal tract damage. Methods: Pre-movement mu and beta ERD, and post-movement beta ERS were analysed in 16 ALS patients and 15 healthy controls performing self-paced brisk right thumb extensions. Apparent diffusion coefficient (ADC) of corticospinal tract was measured with magnetic resonance imaging (MRI). Motor-evoked potentials (MEPs) to the right abductor pollicis brevis were obtained using transcranial magnetic stimulation (TMS). Results: Movement-related electromyographic activity was similar in the two groups. Post-movement ERS was significantly reduced in ALS group and negatively correlated with the amount of corticospinal damage as from MRI and TMS measures. ERD did not significantly differ between groups. Conclusions: Alterations of cortical activity in ALS patients were limited to the post-movement phase, as indicated by reduced ERS, and could be linked to reduced cortical inhibition rather than to generalised hyperexcitability. Significance: The correlation between ERS and corticospinal damage severity might be interpreted as a functional compensation or dysfunction of inhibitory systems paralleling corticospinal damage.",
keywords = "Amyotrophic lateral sclerosis, Cortico-spinal tract, DWI, EEG, Motor neuron disease, Neurophysiology, TMS",
author = "N. Riva and A. Falini and A. Inuggi and Gonzalez-Rosa, {J. J.} and S. Amadio and F. Cerri and R. Fazio and {Del Carro}, U. and M. Comola and G. Comi and L. Leocani",
year = "2012",
month = "8",
doi = "10.1016/j.clinph.2011.12.013",
language = "English",
volume = "123",
pages = "1586--1592",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "8",

}

TY - JOUR

T1 - Cortical activation to voluntary movement in amyotrophic lateral sclerosis is related to corticospinal damage

T2 - Electrophysiological evidence

AU - Riva, N.

AU - Falini, A.

AU - Inuggi, A.

AU - Gonzalez-Rosa, J. J.

AU - Amadio, S.

AU - Cerri, F.

AU - Fazio, R.

AU - Del Carro, U.

AU - Comola, M.

AU - Comi, G.

AU - Leocani, L.

PY - 2012/8

Y1 - 2012/8

N2 - Objectives: The time course of mu and beta sensorimotor rhythms, with event-related desynchronisation (ERD) to preparation and execution of voluntary movement followed by synchronisation (ERS) after movement, is considered to indicate cortical activation and idling, respectively. We investigated ERD and ERS in amyotrophic lateral sclerosis (ALS) patients and the relationship with anatomical and neurophysiological measures of corticospinal tract damage. Methods: Pre-movement mu and beta ERD, and post-movement beta ERS were analysed in 16 ALS patients and 15 healthy controls performing self-paced brisk right thumb extensions. Apparent diffusion coefficient (ADC) of corticospinal tract was measured with magnetic resonance imaging (MRI). Motor-evoked potentials (MEPs) to the right abductor pollicis brevis were obtained using transcranial magnetic stimulation (TMS). Results: Movement-related electromyographic activity was similar in the two groups. Post-movement ERS was significantly reduced in ALS group and negatively correlated with the amount of corticospinal damage as from MRI and TMS measures. ERD did not significantly differ between groups. Conclusions: Alterations of cortical activity in ALS patients were limited to the post-movement phase, as indicated by reduced ERS, and could be linked to reduced cortical inhibition rather than to generalised hyperexcitability. Significance: The correlation between ERS and corticospinal damage severity might be interpreted as a functional compensation or dysfunction of inhibitory systems paralleling corticospinal damage.

AB - Objectives: The time course of mu and beta sensorimotor rhythms, with event-related desynchronisation (ERD) to preparation and execution of voluntary movement followed by synchronisation (ERS) after movement, is considered to indicate cortical activation and idling, respectively. We investigated ERD and ERS in amyotrophic lateral sclerosis (ALS) patients and the relationship with anatomical and neurophysiological measures of corticospinal tract damage. Methods: Pre-movement mu and beta ERD, and post-movement beta ERS were analysed in 16 ALS patients and 15 healthy controls performing self-paced brisk right thumb extensions. Apparent diffusion coefficient (ADC) of corticospinal tract was measured with magnetic resonance imaging (MRI). Motor-evoked potentials (MEPs) to the right abductor pollicis brevis were obtained using transcranial magnetic stimulation (TMS). Results: Movement-related electromyographic activity was similar in the two groups. Post-movement ERS was significantly reduced in ALS group and negatively correlated with the amount of corticospinal damage as from MRI and TMS measures. ERD did not significantly differ between groups. Conclusions: Alterations of cortical activity in ALS patients were limited to the post-movement phase, as indicated by reduced ERS, and could be linked to reduced cortical inhibition rather than to generalised hyperexcitability. Significance: The correlation between ERS and corticospinal damage severity might be interpreted as a functional compensation or dysfunction of inhibitory systems paralleling corticospinal damage.

KW - Amyotrophic lateral sclerosis

KW - Cortico-spinal tract

KW - DWI

KW - EEG

KW - Motor neuron disease

KW - Neurophysiology

KW - TMS

UR - http://www.scopus.com/inward/record.url?scp=84863191533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863191533&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2011.12.013

DO - 10.1016/j.clinph.2011.12.013

M3 - Article

C2 - 22326728

AN - SCOPUS:84863191533

VL - 123

SP - 1586

EP - 1592

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 8

ER -