Cortical activity during olfactory stimulation in multiple chemical sensitivity: a 18F-FDG PET/CT study

Agostino Chiaravalloti, Marco Pagani, Alessandro Micarelli, Barbara Di Pietro, Giuseppe Genovesi, Marco Alessandrini, Orazio Schillaci

Research output: Contribution to journalArticlepeer-review

Abstract

Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.

Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.

Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.

Methods: Two 18F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in 18F-FDG uptake were analysed by statistical parametric mapping (SPM2).

Original languageEnglish
Pages (from-to)733-740
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume42
Issue number5
DOIs
Publication statusPublished - 2015

Keywords

  • Frontal cortex
  • Multiple chemical sensitivity
  • Olfactory cortex
  • Olfactory stimulation
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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