Results: In controls OS led to an increase in glucose consumption in BA 18 and 19 and a reduction in glucose metabolism in BA 10, 11, 32 and 47. In MCS subjects, OS led to an increase in glucose consumption in BA 20, 23, 18 and 37 and a reduction in glucose metabolism in BA 8, 9 and 10.
Conclusion: The results of our study suggest that cortical activity in subjects with MCS differs from that in healthy individuals during olfactory stimulation.
Purpose: To investigate the differences in brain glucose consumption during olfactory stimulation between subjects affected by multiple chemical sensitivity (MCS) and a group of healthy individuals.
Methods: Two 18F-FDG PET/CT scans were performed in 26 subjects (6 men and 20 women; mean age 46.7 ± 11 years) with a clinical diagnosis of MCS and in 11 healthy controls (6 women and 5 men; mean age 45.7 ± 11 years), the first scan after a neutral olfactory stimulation (NS) and the second after a pure olfactory stimulation (OS). Differences in 18F-FDG uptake were analysed by statistical parametric mapping (SPM2).
|Number of pages||8|
|Journal||European Journal of Nuclear Medicine and Molecular Imaging|
|Publication status||Published - 2015|
- Frontal cortex
- Multiple chemical sensitivity
- Olfactory cortex
- Olfactory stimulation
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging