Cortical Alpha Rhythms Are Related to the Anticipation of Sensorimotor Interaction Between Painful Stimuli and Movements: A High-Resolution EEG Study

Claudio Babiloni, Paolo Capotosto, Alfredo Brancucci, Claudio Del Percio, Laura Petrini, Maura Buttiglione, Giuseppe Cibelli, Gian Luca Romani, Paolo Maria Rossini, Lars Arendt-Nielsen

Research output: Contribution to journalArticlepeer-review

Abstract

We tested whether cortical activation anticipating painful stimuli is reduced more by integrative processes on somatosensory painful and motor information relative to the same hand than when that information refers to different hands. In 3 conditions, visual warning stimuli were followed by visual target stimuli associated with an electrical painful stimulation at left index finger. In the Pain (control) condition, no task was required after the target stimuli. In the "Pain + ipsilateral movement" condition, the subjects had to perform a movement of the left index finger. In the "Pain + contralateral movement" condition, they had to perform a movement of the right index finger. Meanwhile, electroencephalographic data were recorded (n = 18) from 128 scalp electrodes. Off line, these data were spatially enhanced by surface Laplacian transformation. Sensorimotor cortical activation before the painful stimulation was probed by the percentage power reduction of alpha rhythms at approximately 8 to 12 Hz (event-related desynchronization, ERD). Results showed that the subjects perceived a lower stimulus intensity in both "Pain + ipsilateral" and "Pain + contralateral" conditions compared with the control "Pain" condition. Furthermore, wide anticipatory alpha ERD (approximately 10-12 Hz) was lower in amplitude in the "Pain + ipsilateral" than in the "Pain + contralateral" condition. These results suggest that modulation of alpha rhythms is a putative physiological mechanism underlying anticipatory processes preceding the integration of painful and motor information at cortical level. Furthermore, these processes show a marked interference ("gating") when the sensorimotor integration refer to the same hand as opposed to both hands. Perspective: We showed that cortical alpha rhythms preceding painful stimulation are influenced by the preparation of contralateral and ipsilateral finger movements. These results motivate further investigation for testing the hypothesis that chronic pain patients might exaggerate the anticipatory activation of sensorimotor cortex to negligible pain stimuli.

Original languageEnglish
Pages (from-to)902-911
Number of pages10
JournalJournal of Pain
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • alpha rhythms
  • event-related desynchronization/synchronization
  • Expectancy
  • hemispheres
  • high-resolution electroencephalography
  • pain
  • sensorimotor interactions

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology

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