Cortical control of cerebellar dentato-rubral and dentato-olivary neurons

Genoveffa Giaquinta, Antonino Casabona, Giuseppe Smecca, Gianfranco Bosco, Vincenzo Perciavalle

Research output: Contribution to journalArticle

Abstract

The cortical input of 117 dentate nucleus neurons projecting either to the red nucleus (73 cells) or to the inferior olive (44 units) was studied electrophysiologically in rats. The majority of cells in both groups responded to electrical stimulation of discrete sites of the contralateral motor cortex. However, activation latencies from the same cortical focus were shorter for neurons projecting to the red nucleus than for olivary-projecting neurons. Principal components analysis pointed out significant differences between the two neuronal subgroups also in the temporal pattern of activity. These results suggest that a motor command might be transmitted through parallel independent channels to cerebellar neurons projecting to different regions of the brainstem.

Original languageEnglish
Pages (from-to)3009-3013
Number of pages5
JournalNeuroReport
Volume10
Issue number14
Publication statusPublished - Sep 29 1999

Keywords

  • Cerebellar dentate nucleus
  • Electrophysiology
  • GABA
  • Inferior olivary complex
  • Motor cortex
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Giaquinta, G., Casabona, A., Smecca, G., Bosco, G., & Perciavalle, V. (1999). Cortical control of cerebellar dentato-rubral and dentato-olivary neurons. NeuroReport, 10(14), 3009-3013.