@article{c10b39ab3d2f43b6a97e391107a3d3f8,
title = "Cortical correlates of behavioural change in amyotrophic lateral sclerosis: Journal of Neurology, Neurosurgery and Psychiatry",
abstract = "Background Behavioural changes in amyotrophic lateral sclerosis (ALS) are heterogeneous. The study aim was to identify the behavioural profiles of non-demented patients with ALS and their neuroimaging correlates and to elucidate if they are comparable to those reported in studies of the behavioural-variant of frontotemporal dementia (bvFTD). Methods Behavioural changes of 102 non-demented patients with ALS were assessed through the Frontal Behavioural Inventory (FBI), a 24-item scale assessing different behavioural modifications, mainly chosen from the core clinical features of FTD. Principal component analysis (PCA) was used to detect distinct clusters of behavioural changes based on FBI subscores. The cortical thinning related to each behavioural profile was analysed in 29 patients with ALS. Cronbach's α was used to test the reliability of bvFTD-related FBI clustering in our cohort. Results Sixty patients with ALS had FBI score≥1. PCA identified three phenotypic clusters loading on disinhibited/hostile, dysexecutive and apathetic FBI subscores. Imaging analyses revealed that the thinning of bilateral orbitofrontal cortex was related to apathy, the right frontotemporal and cingular cortex to the disinhibited/hostile profile and the left precuneus cortex to the dysexecutive behaviours. The bvFTD-associated aggressive profile reliably applied to our cohort. Conclusions In non-demented patients with ALS, different behavioural profiles could be identified. The right frontotemporal and cingular cortex thinning was the hallmark of the behavioural profile mostly overlapping that described in bvFTD. Our findings provide the unbiased identification of determinants relevant for a novel stratification of patients with ALS based on their behavioural impairment, which might be useful as proxy of cognitive decline. {\textcopyright} Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.",
keywords = "amyotrophic lateral sclerosis, behaviour, cortical thickness, frontotemporal dementia, principal component analysis, adult, aggression, Article, behavior change, behavior modification, brain size, cingulate gyrus, clinical feature, controlled study, female, Frontal Behavioral Inventory, hostility, human, major clinical study, male, neuroimaging, neuropsychological test, orbital cortex, precuneus, priority journal, rating scale, aged, apathy, brain cortex, diagnostic imaging, executive function, frontal lobe, middle aged, organ size, parietal lobe, pathology, prefrontal cortex, psychology, temporal lobe, Aged, Aggression, Amyotrophic Lateral Sclerosis, Apathy, Cerebral Cortex, Executive Function, Female, Frontal Lobe, Frontotemporal Dementia, Gyrus Cinguli, Hostility, Humans, Inhibition, Psychological, Male, Middle Aged, Organ Size, Parietal Lobe, Prefrontal Cortex, Principal Component Analysis, Temporal Lobe",
author = "M. Consonni and S.F. Cappa and {Dalla Bella}, E. and V.E. Contarino and G. Lauria",
note = "Cited By :2 Export Date: 10 February 2020 CODEN: JNNPA Correspondence Address: Lauria, G.; 3rd Neurology Unit and Motor Neuron Diseases Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, Italy; email: Giuseppe.LauriaPinter@istitutobesta.it Funding details: Fondazione per la Ricerca Biomedica, FORB Funding details: Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica, AriSLA Funding text 1: Funding The study was financed by institutional funding (IRccs Foundation {\textquoteright}carlo Besta{\textquoteright} Neurological Institute, Ricerca corrente, Italian Ministry of health), Fondazione Regionale per la Ricerca Biomedica (FRRB) Regione Lombardia and Fondazione Italiana di Ricerca per la sLa—sclerosi Laterale amiotrofica (arisLa). References: Strong, M.J., Abrahams, S., Goldstein, L.H., Amyotrophic lateral sclerosis-Frontotemporal spectrum disorder (als-ftsd): Revised diagnostic criteria (2017) Amyotroph Lateral Scler Frontotemporal Degener, 18, pp. 153-174; Consonni, M., Catricala, E., Dalla Bella, E., Beyond the consensus criteria: Multiple cognitive profiles in amyotrophic lateral sclerosis? (2016) Cortex, 81, pp. 162-167; Burke, T., Pinto-Grau, M., Lonergan, K., A cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: Subphenotypes, staging, cognitive predictors, and survival (2017) Ann Clin Transl Neurol, 4, pp. 305-317; Raaphorst, J., Beeldman, E., De Visser, M., A systematic review of behavioural changes in motor neuron disease (2012) Amyotroph Lateral Scler, 13, pp. 493-501; Tsujimoto, M., Senda, J., Ishihara, T., Behavioral changes in early als correlate with voxel-based morphometry and diffusion tensor imaging (2011) J Neurol Sci, 307, pp. 34-40; Machts, J., Loewe, K., Kaufmann, J., Basal ganglia pathology in als is associated with neuropsychological deficits (2015) Neurology, 85, pp. 1301-1309; Borroni, B., Grassi, M., Premi, E., Neuroanatomical correlates of behavioural phenotypes in behavioural variant of frontotemporal dementia (2012) Behav Brain Res, 235, pp. 124-129; O'Connor, C.M., Landin-Romero, R., Clemson, L., Behavioral-variant frontotemporal dementia: Distinct phenotypes with unique functional profiles (2017) Neurology, 89, pp. 570-577; Brooks, B.R., Miller, R.G., Swash, M., El escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis (2000) Amyotroph Lateral Scler Other Motor Neuron Disord, 1, pp. 293-299; Rascovsky, K., Hodges, J.R., Knopman, D., Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia (2011) Brain, 134, pp. 2456-2477; Consonni, M., Iannaccone, S., Cerami, C., The cognitive and behavioural profile of amyotrophic lateral sclerosis: Application of the consensus criteria (2013) Behav Neurol, 27, pp. 143-153; Alberici, A., Geroldi, C., Cotelli, M., The frontal behavioural inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease (2007) Neurol Sci, 28, pp. 80-86; Field, A., (2013) Discovering statistics using IBM SPSS statistics, , 4th eds. London: Sage publication; Consonni, M., Contarino, V.E., Catricala, E., Cortical markers of cognitive syndromes in amyotrophic lateral sclerosis (2018) Neuroimage Clin, 19, pp. 675-682; Fischl, B., Dale, A.M., Measuring the thickness of the human cerebral cortex from magnetic resonance images (2000) Proc Natl Acad Sci U S A, 97, pp. 11050-11055; Destrieux, C., Fischl, B., Dale, A., Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature (2010) Neuroimage, 53, pp. 1-15; Agosta, F., Valsasina, P., Riva, N., The cortical signature of amyotrophic lateral sclerosis (2012) PLoS One, 7, p. e42816; Goldstein, L.H., Abrahams, S., Changes in cognition and behaviour in amyotrophic lateral sclerosis: Nature of impairment and implications for assessment (2013) Lancet Neurol, 12, pp. 368-380; Lillo, P., Mioshi, E., Zoing, M.C., How common are behavioural changes in amyotrophic lateral sclerosis? (2011) Amyotroph Lateral Scler, 12, pp. 45-51; Gibbons, Z.C., Richardson, A., Neary, D., Behaviour in amyotrophic lateral sclerosis (2008) Amyotroph Lateral Scler, 9, pp. 67-74; De Silva, D., Hsieh, S., Caga, J., Motor function and behaviour across the als-ftd spectrum (2016) Acta Neurol Scand, 133, pp. 367-372; Grossman, A.B., Woolley-Levine, S., Bradley, W.G., Detecting neurobehavioral changes in amyotrophic lateral sclerosis (2007) Amyotroph Lateral Scler, 8, pp. 56-61; Montuschi, A., Iazzolino, B., Calvo, A., Cognitive correlates in amyotrophic lateral sclerosis: A population-based study in Italy (2015) J Neurol Neurosurg Psychiatry, 86, pp. 168-173; Witgert, M., Salamone, A.R., Strutt, A.M., Frontal-lobe mediated behavioral dysfunction in amyotrophic lateral sclerosis (2010) Eur J Neurol, 17, pp. 103-110; Palmieri, A., Naccarato, M., Abrahams, S., Right hemisphere dysfunction and emotional processing in als: An FMRI study (2010) J Neurol, 257, pp. 1970-1978; Zamboni, G., Huey, E.D., Krueger, F., Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates (2008) Neurology, 71, pp. 736-742; Agosta, F., Ferraro, P.M., Riva, N., Structural brain correlates of cognitive and behavioral impairment in mnd (2016) Hum Brain Mapp, 37, pp. 1614-1626; Broe, M., Hodges, J.R., Schofield, E., Staging disease severity in pathologically confirmed cases of frontotemporal dementia (2003) Neurology, 60, pp. 1005-1011; Wittenberg, D., Possin, K.L., Rascovsky, K., The early neuropsychological and behavioral characteristics of frontotemporal dementia (2008) Neuropsychol Rev, 18, pp. 91-102; Reijnders, J.S., Scholtissen, B., Weber, W.E., Neuroanatomical correlates of apathy in Parkinson's disease: A magnetic resonance imaging study using voxel-based morphometry (2010) Mov Disord, 25, pp. 2318-2325; Yan, H., Onoda, K., Yamaguchi, S., Gray matter volume changes in the apathetic elderly (2015) Front Hum Neurosci, 9, p. 318; Abrahams, S., Goldstein, L.H., Kew, J.J., Frontal lobe dysfunction in amyotrophic lateral sclerosis. A pet study (1996) Brain, 119, pp. 2105-2120; Verstraete, E., Veldink, J.H., Mandl, R.C., Impaired structural motor connectome in amyotrophic lateral sclerosis (2011) PLoS One, 6, p. e24239; Strong, M.J., Grace, G.M., Freedman, M., Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis (2009) Amyotroph Lateral Scler, 10, pp. 131-146; Radakovic, R., Stephenson, L., Colville, S., Multidimensional apathy in als: Validation of the dimensional apathy scale (2016) J Neurol Neurosurg Psychiatry, 87, pp. 663-669; Santangelo, G., Siciliano, M., Trojano, L., Apathy in amyotrophic lateral sclerosis: Insights from dimensional apathy scale (2017) Amyotroph Lateral Scler Frontotemporal Degener, 18, pp. 434-442; Caga, J., Turner, M.R., Hsieh, S., Apathy is associated with poor prognosis in amyotrophic lateral sclerosis (2016) Eur J Neurol, 23, pp. 891-897; Chio, A., Hammond, E.R., Mora, G., Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis (2015) J Neurol Neurosurg Psychiatry, 86, pp. 38-44",
year = "2019",
doi = "10.1136/jnnp-2018-318619",
language = "English",
volume = "90",
pages = "380--386",
journal = "J. Neurol. Neurosurg. Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",
}